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Intangible assets and goodwill - (Tables)

12 Months Ended

Dec. 31, 2024

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of definite lived intangible assets

Definite lived intangible assets consisted of the following at December 31, 2024 and 2023:

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Ending Balance at

​

​

​

​

​

Reclass from

​

​

Foreign

​

​

Ending Balance at

Definite-lived

​

​

December 31,

​

​

​

​

​

Indefinite Lived to

​

​

currency

​

​

December 31,

intangibles assets, gross

​

2023

​

Additions

​

Definite Lived

​

​

translation

​

2024

Emflaza

​

$

527,417

​

$

—

​

$

—

​

$

—

​

$

527,417

Waylivra

​

​

10,218

​

​

2,874

​

​

—

​

​

(695)

​

​

12,397

Tegsedi

​

​

13,322

​

​

5,936

​

​

—

​

​

(1,009)

​

​

18,249

Kebilidi

​

​

—

​

​

—

​

​

10,731

​

​

—

​

​

10,731

Upstaza

​

​

89,550

​

​

—

​

​

17,387

​

​

—

​

​

106,937

Total definite-lived intangibles, gross

​

$

640,507

​

$

8,810

​

$

28,118

​

$

(1,704)

​

$

675,731

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Ending Balance at

​

​

​

​

​

Foreign

​

​

Ending Balance at

Definite-lived

​

​

December 31,

​

​

​

​

​

currency

​

​

December 31,

intangibles assets, accumulated amortization

​

2023

​

Amortization

​

translation

​

2024

Emflaza

​

$

(478,618)

​

$

(48,799)

​

$

—

​

$

(527,417)

Waylivra

​

​

(3,965)

​

​

(1,602)

​

​

294

​

​

(5,273)

Tegsedi

​

​

(3,311)

​

​

(2,581)

​

​

283

​

​

(5,609)

Kebilidi

​

​

—

​

​

(112)

​

​

—

​

​

(112)

Upstaza

​

​

(10,882)

​

​

(7,644)

​

​

—

​

​

(18,526)

Total definite-lived intangibles, accumulated amortization

​

$

(496,776)

​

$

(60,738)

​

$

577

​

$

(556,937)

​

​

​

​

​

​

​

​

​

​

​

​

​

Total definite-lived intangibles, net

​

​

​

​

​

​

​

​

​

​

$

118,794

Schedule of estimated future amortization of intangible assets

The estimated future amortization of the Emflaza rights, Waylivra, Tegsedi, and Upstaza/Kebilidi intangible assets is expected to be as follows:

​

​	​	​	​
​		As of December 31, 2024
2025	​	$	14,374
2026	​		14,364
2027	​		14,364
2028	​		14,364
2029 and thereafter	​		61,328
Total	​	$	118,794

Schedule of indefinite lived intangible assets

Indefinite lived intangible assets consisted of the following at December 31, 2024 and 2023:

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Ending Balance at

​

​

​

​

​

Reclass from

​

​

Priority Review

​

​

​

​

​

Ending Balance at

Indefinite-lived

​

​

December 31,

​

​

​

​

​

Indefinite Lived to

​

​

Voucher Book Value

​

​

​

​

​

December 31,

intangibles assets

​

2023

​

Additions

​

Definite Lived

​

​

Derecognized Upon Sale

​

​

Impairment

​

2024

PTC AADC (Upstaza and Kebilidi)

​

$

235,766

​

$

—

​

$

(28,118)

​

$

(48,100)

​

$

(159,548)

​

$

—

Total indefinite-lived intangibles

​

$

235,766

​

$

—

​

$

(28,118)

​

$

(48,100)

​

$

(159,548)

​

$

—

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Total intangible assets, net

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

$

118,794

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- References

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- Definition

Tabular disclosure of assets, excluding financial assets and goodwill, lacking physical substance with a finite life, by either major class or business segment.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 55
-Paragraph 40
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482640/350-30-55-40

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482665/350-30-50-2

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- Definition

Tabular disclosure of assets, excluding financial assets and goodwill, lacking physical substance and exist in perpetuity, by either major class or business segment.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 55
-Paragraph 40
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482640/350-30-55-40

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482665/350-30-50-2

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- Definition

Tabular disclosure of the amount of amortization expense expected to be recorded in succeeding fiscal years for finite-lived intangible assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 55
-Paragraph 40
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482640/350-30-55-40

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)(3)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482665/350-30-50-2

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