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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 22, 2017
Dec. 31, 2024
USD ($)
Dec. 31, 2024
USD ($)
segment
Dec. 31, 2024
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2024
USD ($)
item
Dec. 31, 2024
USD ($)
country
Dec. 31, 2023
USD ($)
country
segment
Dec. 31, 2022
USD ($)
segment
country
Dec. 31, 2019
USD ($)
Jan. 01, 2029
USD ($)
Jul. 01, 2027
USD ($)
Jul. 31, 2025
USD ($)
Jun. 30, 2024
USD ($)
Jun. 30, 2022
USD ($)
Jun. 01, 2022
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Number of reporting segments     1     1   1 1                
Number of operating segments | segment     1         1 1                
Allowance for credit loss   $ 0 $ 0 $ 0 $ 0 $ 0 $ 0 $ 0                  
Increase in allowance for credit losses       0       0                  
Allowance for doubtful accounts receivable   2,300 2,300 2,300 $ 2,300 2,300 2,300 1,200                  
Bad debt expense       1,700       900 $ 200                
Revenue       806,780       937,822 698,801                
State income tax provision       19,419       $ (27,226) $ 4,224                
Income taxes                                  
Federal income tax statutory rate 21.00%       21.00%     21.00% 21.00%                
Deferred tax liability   11,740 11,740 11,740 $ 11,740 11,740 11,740 $ 63,388                  
Deferred tax benefit       55,912       46,930 $ 34,276                
Non cash realized foreign exchange loss                 16,887                
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174.       62,500                          
Impairment of indefinite-lived intangibles excluding goodwill   159,500   159,548       217,800 $ 33,384                
Impairment of goodwill       0                          
Indefinite-lived intangible assets                                  
Income taxes                                  
Impairment of indefinite-lived intangibles excluding goodwill       159,548                          
Agilis                                  
Income taxes                                  
Deferred tax liability                                 $ 122,000
Impairment of goodwill       0                          
Prepaids and other current assets                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Deferred research and development advance payments, short-term   7,400 7,400 7,400 7,400 7,400 7,400 2,600                  
Deposits and other assets                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Bank guarantee denominated in foreign currency   600 600 600 600 600 600                    
Deferred research and development advance payments, long-term   1,700 1,700 1,700 1,700 1,700 1,700 4,700                  
Hopewell Campus                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Letters of credit                         $ 3,000 $ 5,000      
Hopewell Campus | Minimum                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Term for letter of credit (in years)                   5 years              
Hopewell Campus | Deposits and other assets                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Letters of credit                   $ 7,500              
Hopewell Campus | Fifth Anniversary                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Letters of credit                   $ 3,800              
Term for letter of credit (in years)                   5 years              
Warren Premises                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Letters of credit                               $ 8,100  
Warren Premises | Deposits and other assets                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Letters of credit                             $ 8,100    
Warren Building under lease amendment                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Letters of credit   10,000 10,000 10,000 10,000 10,000 10,000       $ 2,500 $ 5,000          
Warren Building under lease amendment | Deposits and other assets                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Letters of credit   $ 10,000 $ 10,000 10,000 $ 10,000 $ 10,000 $ 10,000                    
Non-US                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       393,736       406,161                  
United States                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       413,044       $ 531,661                  
Net product revenue | Geographic concentration risk                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Number of countries exceeding 10% of net product sales | country             3 2 2                
Percentage of net product sales threshold         10.00%     10.00% 10.00%                
Net product revenue | Customer concentration risk                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Percentage of net product sales threshold         10.00%     10.00% 10.00%                
Product                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       600,951       $ 661,249 $ 535,228                
Product | Non-US                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       393,800       406,100 316,900                
Product | Net product revenue | Geographic concentration risk | Russia                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       105,400       86,000 59,700                
Product | Net product revenue | Geographic concentration risk | Brazil                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       72,100                          
Product | Net product revenue | Geographic concentration risk | United States                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       207,200       255,100 218,300                
Emflaza | United States                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       207,200       255,100 218,300                
Translarna | Non-US                                  
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                                  
Revenue       $ 339,900       $ 355,800 $ 288,600