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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details)	1 Months Ended	12 Months Ended
	Jul. 31, 2022 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Fair Value Valuation Inputs
Fair value			$ 36,300,000
Milestone Payable		$ 11,025,000	2,500,000
Development and Regulatory Milestones
Fair Value Valuation Inputs
Potential developmental and regulatory milestones		0
Net Sales Milestones
Fair Value Valuation Inputs
Remaining potential milestones		800,000
Agilis
Fair Value Valuation Inputs
Milestone obligation payments made	$ 50,000,000
Potential developmental and regulatory milestones		0
Agilis | Accounts payable and accrued expenses
Fair Value Valuation Inputs
Milestone Payable		11,000,000
Agilis | Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone
Fair Value Valuation Inputs
Potential milestones		0
Agilis | Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum
Fair Value Valuation Inputs
Potential milestones			0
Agilis | Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum
Fair Value Valuation Inputs
Potential milestones			$ 31,000,000
Agilis | Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			0.85
Agilis | Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			0.92
Agilis | Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			0.058
Agilis | Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			0.061
Agilis | Development and Regulatory Milestones | Significant unobservable inputs (Level 3)
Fair Value Valuation Inputs
Fair value		0
Agilis | Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Commitments
Fair Value Valuation Inputs
Fair value			$ 26,600,000	$ 82,500,000
Agilis | Regulatory Milestones
Fair Value Valuation Inputs
Milestone obligation payments made		20,000,000
Agilis | Net Sales Milestones | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum
Fair Value Valuation Inputs
Potential milestones		0	0
Agilis | Net Sales Milestones | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum
Fair Value Valuation Inputs
Potential milestones		$ 50,000,000	$ 50,000,000
Agilis | Net Sales Milestones | Commitments | Valuation Technique, Option Pricing Model | Probability of Success
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		1
Agilis | Net Sales Milestones | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			0.85
Agilis | Net Sales Milestones | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			1
Agilis | Net Sales Milestones | Commitments | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			0
Agilis | Net Sales Milestones | Commitments | Valuation Technique, Option Pricing Model | Discount Rate
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.15	0.11
Agilis | Net Sales Milestones | Upstaza | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		1
Agilis | Net Sales Milestones | Upstaza | Valuation Technique, Option Pricing Model | Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.15
Agilis | Net Sales Milestones | Significant unobservable inputs (Level 3)
Fair Value Valuation Inputs
Fair value		$ 800,000
Agilis | Net Sales Milestones | Significant unobservable inputs (Level 3) | Commitments
Fair Value Valuation Inputs
Fair value			$ 9,700,000

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