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Leases - Narrative (Details)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
USD ($)
ft²
building
Jun. 17, 2024
USD ($)
ft²
component
Jun. 01, 2022
USD ($)
ft²
period
building
Dec. 31, 2024
USD ($)
ft²
building
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Jan. 01, 2029
USD ($)
Jul. 01, 2027
USD ($)
Jul. 31, 2025
USD ($)
Jun. 30, 2024
USD ($)
Jun. 16, 2024
ft²
component
Leases                      
Operating lease, expense       $ 24,900 $ 29,000 $ 25,200          
Finance lease liabilities- current $ 3,000     3,000 3,000            
Finance lease liabilities- noncurrent 15,574     15,574 17,184            
Aggregate rent, Initial term 127,665     127,665              
Operating lease ROU assets 56,685     56,685 $ 91,896            
Operating Lease, Liability $ 85,310     $ 85,310              
Incremental borrowing rate used to remeasure ROU liability 7.64%     7.64% 8.69%            
Gain on lease modification       $ (5,464)              
Gain on termination of lease components       2,179              
MassBio                      
Leases                      
Finance lease cost       1,400 $ 1,500            
Finance lease liabilities- current $ 3,000     3,000 3,000            
Finance lease liabilities- noncurrent $ 15,600     $ 15,600 $ 17,200            
Minimum                      
Leases                      
Operating lease, term of contract 1 month 6 days     1 month 6 days              
Maximum                      
Leases                      
Operating lease, term of contract 14 years 4 months 24 days     14 years 4 months 24 days              
Renewal term 15 years     15 years              
Hopewell Campus                      
Leases                      
Area of real estate property | ft²   93,461                 220,500
Operating lease ROU assets   $ 1,600                  
Operating Lease, Liability   $ 1,600                  
Letters of credit                 $ 3,000 $ 5,000  
Number of separate lease components | component                     4
Number of separate lease components terminated | component   3                  
Gain on termination of lease components       $ 2,200              
Incremental borrowing rate of interest used to remeasure the remaining components of operating lease   7.50%                  
Return of letter of credit pertaining to amendments to operating lease agreement   $ 2,500                  
Warren Premises                      
Leases                      
Operating lease, term of contract     17 years                
Number of buildings leased | building     2                
Area of real estate property | ft²     360,000                
Renewal term     5 years                
Number of renewable terms | period     3                
Lessee, Operating Lease, Existence of Option to Extend [true false]     true                
Aggregate rent, Initial term     $ 163,000                
Base rent abatement period     3 years                
Base rent abatement     $ 18,600                
Aggregate rent net of base rate abatement, initial term     144,400                
Allowance for lease improvements     36,100                
Letters of credit     $ 8,100                
Warren Building under lease amendment                      
Leases                      
Number of buildings leased | building 1     1              
Area of real estate property | ft² 180,000     180,000              
Aggregate base rent due after 2027 under terms of lease amendment $ 57,700     $ 57,700              
Amount of total reduction in lease obligation from initial base rate obligation resulting from lease amendment 57,700     57,700              
Allowance for lease improvements 23,900     23,900              
Letters of credit 10,000     $ 10,000     $ 2,500 $ 5,000      
Gain on lease modification $ 5,500                    
Incremental borrowing rate of interest used to remeasure the remaining components of operating lease 7.80%