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Consolidated Statements of Stockholders' Equity/(Deficit) - USD ($)
$ in Thousands
Common stock
Additional paid-in capital
Accumulated other comprehensive (loss) income
Accumulated deficit
Total
Balance (in shares) at Dec. 31, 2021 70,828,226        
Balance at the beginning of the period at Dec. 31, 2021 $ 71 $ 2,123,606 $ (24,282) $ (2,097,957) $ 1,438
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to stock purchase agreement (in shares) 1,095,290        
Issuance of common stock related to stock purchase agreement $ 1 49,999     50,000
Exercise of options (in shares) 496,863        
Exercise of options   14,632     14,632
Restricted stock vesting and issuance (in shares) 490,008        
Issuance of common stock in connection with an employee stock purchase plan (in shares) 194,305        
Issuance of common stock in connection with an employee stock purchase plan   6,450     6,450
Share-based compensation expense   110,333     110,333
Net Income (Loss)       (559,017) (559,017)
Comprehensive income (loss)     29,078   29,078
Balance (in shares) at Dec. 31, 2022 73,104,692        
Balance at the end of the period at Dec. 31, 2022 $ 72 2,305,020 4,796 (2,656,974) (347,086)
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 822,482        
Exercise of options $ 1 24,039     24,040
Restricted stock vesting and issuance (in shares) 915,203        
Restricted stock vesting and issuance, net $ 1       1
Issuance of common stock in connection with an employee stock purchase plan (in shares) 209,050        
Issuance of common stock in connection with an employee stock purchase plan   5,954     5,954
Issuance of common stock in connection with a milestone payable (in shares) 657,462        
Issuance of common stock in connection with a milestone payable $ 1 29,569     29,570
Share-based compensation expense   101,636     101,636
Receivable from investor   15     15
Net Income (Loss)       (626,604) (626,604)
Comprehensive income (loss)     (6,081)   (6,081)
Balance (in shares) at Dec. 31, 2023 75,708,889        
Balance at the end of the period at Dec. 31, 2023 $ 75 2,466,233 (1,285) (3,283,578) (818,555)
Increase (Decrease) in Stockholders' Equity          
Retired shares (in shares) (20)        
Exercise of options (in shares) 824,813        
Exercise of options $ 1 28,564     28,565
Restricted stock vesting and issuance (in shares) 963,543        
Restricted stock vesting and issuance, net $ 1       1
Issuance of common stock in connection with an employee stock purchase plan (in shares) 206,963        
Issuance of common stock in connection with an employee stock purchase plan   5,199     5,199
Share-based compensation expense   74,615     74,615
Net Income (Loss)       (363,295) (363,295)
Comprehensive income (loss)     (24,601)   (24,601)
Balance (in shares) at Dec. 31, 2024 77,704,188        
Balance at the end of the period at Dec. 31, 2024 $ 77 $ 2,574,611 $ (25,886) $ (3,646,873) $ (1,098,071)