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Stock award plan - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended		12 Months Ended
	Jun. 08, 2022	Dec. 31, 2022	Dec. 31, 2020	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Apr. 30, 2022	Jun. 30, 2021	May 31, 2021	Jan. 31, 2020
Stock option plan
Share-based compensation expense				$ 74,615	$ 101,636	$ 110,333
Unrecognized compensation cost				$ 99,000
Weighted average remaining service period for recognition of unrecognized compensation cost				2 years 3 months 18 days
Stock option
Stock option plan
Granted (in shares)				970,875	1,117,284	1,685,435
Options forfeited (in shares)				1,263,972	2,196,820	458,737
Expected dividend yield (as a percent)				0.00%	0.00%	0.00%
Weighted average grant date fair value (in dollars per share)				$ 14.04	$ 21.27	$ 23.54
Stock option | Maximum
Stock option plan
Vesting period				4 years
Employee Stock Purchase Plan
Stock option plan
Number of shares authorized (in shares)								2,000,000	1,000,000
Award requisite service period				6 months
Share-based compensation expense				$ 2,200
Employee Stock Purchase Plan | Minimum
Stock option plan
Purchase price of common stock, percent				85.00%
Employee stock purchase plan, voting percentage limit				5.00%
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan
Stock option plan
Number of shares available for issuance				0
Amended 2013 LTIP
Stock option plan
Number of shares available for issuance				6,893,006
Number of additional shares authorized (in shares)	8,475,000
Amended 2013 LTIP | Maximum
Stock option plan
Number of shares authorized (in shares)	16,724,212
2020 Inducement Stock Incentive Plan
Stock option plan
Number of shares available for issuance				1,923,916
Number of additional shares authorized (in shares)			1,000,000
2020 Inducement Stock Incentive Plan | Maximum
Stock option plan
Number of shares authorized (in shares)										1,000,000
2020 Inducement Stock Incentive Plan | Common stock | Maximum
Stock option plan
Number of shares authorized (in shares)							1,300,000
Number of additional shares authorized (in shares)		1,700,000
2020 Inducement Stock Incentive Plan | Stock option
Stock option plan
Granted (in shares)				61,720
Stockholder's specified ownership percentage				10.00%
Expiration period				10 years
Granted (in dollars per share)				$ 36.62
Options forfeited (in shares)				532,930
2020 Inducement Stock Incentive Plan | Stock option | Minimum
Stock option plan
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date				100.00%
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date				110.00%
2020 Inducement Stock Incentive Plan | Restricted stock units
Stock option plan
Granted (in shares)				84,985
Units forfeited (in shares)				12,977

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Employee Stock Purchase Plan, Voting Percentage Limit, Percent

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