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Stock award plan - Restricted Stock (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Number of Shares          
Share-based compensation expense     $ 74,615 $ 101,636 $ 110,333
Unvested restricted stock units          
Number of Shares          
Balance at the beginning of the period (in shares)     2,866,270    
Granted (in shares)     1,897,100    
Vested (in shares)     (963,543)    
Forfeited (in shares)     (272,252)    
Balance at the end of the period (in shares) 3,527,575 2,866,270 3,527,575 2,866,270  
Weighted Average Grant Date Fair Value          
Balance at the beginning of the period (in dollars per share)     $ 41.82    
Granted (in dollars per share)     26.29    
Vested (in dollars per share)     43.67    
Forfeited (in dollars per share)     36.29    
Balance at the end of the period (in dollars per share) $ 33.39 $ 41.82 $ 33.39 $ 41.82  
Performance-based restricted stock units (PSUs)          
Number of Shares          
Share-based compensation expense     $ 0    
Chief Executive Officer | Performance-based restricted stock units (PSUs) - Development, regulatory or commercial goals          
Number of Shares          
Granted (in shares) 25,000 150,000      
Performance period 5 years 2 years      
Chief Executive Officer | Performance-based restricted stock units (PSUs) - Stock price goals          
Number of Shares          
Granted (in shares) 31,250        
Performance period 5 years