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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Stock option plan
Share-based compensation expense	$ 74,615	$ 101,636	$ 110,333
Unrecognized compensation cost	$ 99,000
Weighted average remaining service period for recognition of unrecognized compensation cost	2 years 3 months 18 days
Research and development
Stock option plan
Share-based compensation expense	$ 36,629	52,941	55,869
Selling, general and administrative
Stock option plan
Share-based compensation expense	$ 37,986	$ 48,695	$ 54,464

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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