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Revenue recognition - Net Product Sales (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2024 USD ($) Distributor country segment	Dec. 31, 2023 USD ($) country Distributor segment	Dec. 31, 2022 USD ($) segment country Distributor
Revenue recognition
Number of operating segments | segment	1	1	1
Revenue	$ 806,780	$ 937,822	$ 698,801
United States
Revenue recognition
Revenue	413,044	531,661
Non-US
Revenue recognition
Revenue	393,736	406,161
Net product revenue
Revenue recognition
Contract with customer, liability	$ 0	$ 0
Net product revenue | Geographic concentration risk
Revenue recognition
Number of countries exceeding 10% of net product sales | country	3	2	2
Percentage of net product sales threshold	10.00%	10.00%	10.00%
Net product revenue | Customer concentration risk
Revenue recognition
Number of distributors | Distributor	2	2	2
Percentage of net product sales threshold	10.00%	10.00%	10.00%
Product
Revenue recognition
Revenue	$ 600,951	$ 661,249	$ 535,228
Product | Non-US
Revenue recognition
Revenue	393,800	406,100	316,900
Product | Net product revenue | Geographic concentration risk | United States
Revenue recognition
Revenue	207,200	255,100	218,300
Product | Net product revenue | Geographic concentration risk | Russia
Revenue recognition
Revenue	105,400	86,000	59,700
Product | Net product revenue | Geographic concentration risk | Brazil
Revenue recognition
Revenue	72,100
Emflaza | United States
Revenue recognition
Revenue	207,200	255,100	218,300
Translarna | Non-US
Revenue recognition
Revenue	$ 339,900	$ 355,800	$ 288,600

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