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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands	1 Months Ended	12 Months Ended
	Sep. 30, 2022 USD ($)	Dec. 31, 2024 USD ($) product	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Nov. 30, 2011 USD ($)
Revenue recognition
Number of approved products | product		2
Remaining potential milestones that can be achieved		$ 150,000
Revenue		806,780	$ 937,822	$ 698,801
Collaboration revenue
Revenue recognition
Revenue		304	100,030	50,052
Royalty revenue
Revenue recognition
Revenue		$ 203,864	168,856	113,521
SMA License Agreement
Revenue recognition
Number of approved products | product		1
SMA License Agreement | Collaboration revenue
Revenue recognition
Revenue			100,000	50,100
SMA License Agreement | Royalty revenue
Revenue recognition
Revenue		$ 203,900	168,900	$ 113,500
Research And Development Event Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved		0
Sales Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved		$ 150,000
Net sales milestone threshold achieved	$ 750,000		1,500,000
Sales Milestones | SMA License Agreement | Prepaids and other current assets
Revenue recognition
Milestone payments due	$ 50,000		$ 100,000
Maximum | Research And Development Event Milestones | SMA License Agreement | Roche
Revenue recognition
Remaining potential milestones that can be achieved					$ 135,000
Maximum | Sales Milestones | SMA License Agreement | Roche
Revenue recognition
Remaining potential milestones that can be achieved					$ 325,000

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