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Income taxes - Tax Rate Reconciliation (Details)		12 Months Ended
	Dec. 22, 2017	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Reconciliation of the U.S. statutory income tax rate to the entity's effective tax rate
Federal income tax provision at statutory rate	21.00%	21.00%	21.00%	21.00%
State income tax provision, net of federal benefit		(1.57%)	0.32%	3.07%
Permanent differences		11.79%	(1.43%)	(1.83%)
Research and development		5.07%	4.59%	5.89%
Change in valuation allowances		(27.99%)	(16.86%)	(23.36%)
Change in deferred tax assets				(0.10%)
Foreign tax rate differential		9.14%	0.05%	(0.17%)
Tax rate change		(11.69%)	(1.26%)	0.34%
Release (accrual) of uncertain tax positions		(5.90%)	3.71%
Other		0.13%	(0.12%)
Effective income tax rate		(0.02%)	10.00%	4.84%

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in deferred tax assets.

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