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Segment and Geographic information - Significant Expenses by Segment (Details)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
USD ($)
segment
Dec. 31, 2023
USD ($)
segment
Dec. 31, 2022
USD ($)
segment
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]      
Number of Operating Segments | segment 1 1 1
Total revenues $ 806,780 $ 937,822 $ 698,801
Net loss attributable to common stockholders (363,295) (626,604) (559,017)
Operating segments | Life Science      
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]      
Total revenues 806,780 937,822 698,801
Cost of Product Sales 26,901 27,404 15,355
Program Spend 211,230 258,705 292,044
Employee Costs 251,184 334,305 298,716
Manufacturing Costs 64,120 86,641 108,032
Administrative Costs 72,420 70,531 68,001
Occupancy Costs 34,913 42,085 38,260
Milestones 65,000 30,000  
Other segment items 444,307 714,755 437,410
Net loss attributable to common stockholders $ (363,295) $ (626,604) $ (559,017)
Other segment items - composition and description Other segment items includes cost of goods sold (“COGS”) amortization of intangible assets, COGS royalty, travel and expense, distribution costs, bad debt expense, finance costs, depreciation and amortization, contract labor costs, stock compensation expense, intangible impairment expense, change in the fair value of contingent consideration, interest expense, net, other income/expense, gain on the sale of the PRV, loss on extinguishment of debt, and income tax expense (benefit). Other segment items includes cost of goods sold (“COGS”) amortization of intangible assets, COGS royalty, travel and expense, distribution costs, bad debt expense, finance costs, depreciation and amortization, contract labor costs, stock compensation expense, intangible impairment expense, change in the fair value of contingent consideration, interest expense, net, other income/expense, gain on the sale of the PRV, loss on extinguishment of debt, and income tax expense (benefit). Other segment items includes cost of goods sold (“COGS”) amortization of intangible assets, COGS royalty, travel and expense, distribution costs, bad debt expense, finance costs, depreciation and amortization, contract labor costs, stock compensation expense, intangible impairment expense, change in the fair value of contingent consideration, interest expense, net, other income/expense, gain on the sale of the PRV, loss on extinguishment of debt, and income tax expense (benefit).
Eliminations And reconciling items      
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]      
Net loss attributable to common stockholders $ 0 $ 0 $ 0