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Intangible assets and goodwill - Indefinite-lived Intangibles (Details)	3 Months Ended	12 Months Ended
	Dec. 31, 2024 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Indefinite-lived intangibles
Impairment	$ (159,500,000)	$ (159,548,000)	$ (217,800,000)	$ (33,384,000)
Intangible assets, net	118,794,000	118,794,000	379,497,000
Proceeds from sale of priority review voucher		150,000,000
Accrued brokerage fees in connection with sale of priority review voucher	2,000,000	2,000,000
Gain on sale of priority review voucher		99,900,000
Accounts payable and accrued expenses
Indefinite-lived intangibles
Accrued brokerage fees in connection with sale of priority review voucher	2,000,000	2,000,000
Indefinite-lived intangible assets
Indefinite-lived intangibles
Beginning Balance		235,766,000
Reclass from Indefinite-Lived to Definite-Lived		(28,118,000)
Priority Review Voucher Book Value Derecognized Upon Sale		(48,100,000)
Impairment		(159,548,000)
Ending Balance	$ 0	$ 0	235,766,000
Indefinite-lived intangible assets | Significant unobservable inputs (Level 3) | Valuation Technique, Discounted Cash Flow | Discount Rate
Indefinite-lived intangibles
Indefinite-lived intangible asset, measurement input	0.15	0.15
Indefinite-lived intangible assets | Significant unobservable inputs (Level 3) | Valuation Technique, Discounted Cash Flow | Probability of success
Indefinite-lived intangibles
Indefinite-lived intangible asset, measurement input	1	1
Indefinite-lived intangible assets | PTC AADC
Indefinite-lived intangibles
Beginning Balance		$ 235,766,000
Reclass from Indefinite-Lived to Definite-Lived		(28,118,000)
Priority Review Voucher Book Value Derecognized Upon Sale		(48,100,000)
Impairment		(159,548,000)
Ending Balance			235,766,000
Indefinite-lived intangible assets | Agilis | PTC AADC
Indefinite-lived intangibles
Beginning Balance		$ 48,100,000
Ending Balance			$ 48,100,000

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The cash inflow from the sale of a priority review voucher granted by the FDA to drug developers.

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Amount of impairment loss resulting from write-down of assets, excluding financial assets and goodwill, lacking physical substance and having a projected indefinite period of benefit to fair value.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 45
-Paragraph 2
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482686/350-30-45-2

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Amount of assets, excluding financial assets and goodwill, lacking physical substance and having a projected indefinite period of benefit.

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Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 350
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Sum of the carrying amounts of all intangible assets, excluding goodwill, as of the balance sheet date, net of accumulated amortization and impairment charges.

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-Topic 350
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