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Stock award plan - (Tables)

3 Months Ended

Mar. 31, 2025

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2024		8,482,489	​	$	42.29				​	​
Granted		802,745	​	$	46.74				​	​
Exercised		(431,089)	​	$	36.98				​	​
Forfeited/Cancelled		(320,327)	​	$	50.32				​	​
Outstanding at March 31, 2025		8,533,818	​	$	42.68		5.93	years	​	$	91,932
Expected to vest at March 31, 2025		1,802,150	​	$	38.47		8.81	years	​	$	22,683
Exercisable at March 31, 2025		6,512,960	​	$	43.96		5.02	years	​	$	66,629

​

Schedule of assumptions used to estimate fair values of grants made on the date of grant

​

​	​	​	​
​		Three months ended
​		March 31, 2025
Risk-free interest rate		4.12% - 4.44%
Expected volatility		55%
Expected term		5.5 years

Summary of information on the Company's restricted stock

​

​	​	​	​	​	​
​	​	Restricted Stock Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2024	​	3,527,575	​	$	33.39
Granted		1,537,675	​	​	46.76
Vested		(1,089,999)	​	​	36.71
Forfeited		(102,270)	​	​	33.26
Unvested at March 31, 2025		3,872,981	​	$	37.77

Schedule of share-based compensation expense recorded in the statement of operations

​

​	​	​	​	​	​	​	​
​	​	Three Months Ended March 31,					​
​		2025			2024
Research and development	​	$	8,663	​	$	8,967	​
Selling, general and administrative	​		9,397	​		9,411	​
Total	​	$	18,060	​	$	18,378	​

​

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Name Accounting Standards Codification
-Section 50
-Subparagraph (c)
-Paragraph 2
-SubTopic 10
-Topic 718
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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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