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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2025	Mar. 31, 2024
Stock option plan
Share-based compensation expense	$ 18,060	$ 18,378
Unrecognized compensation cost	$ 170,300
Weighted average remaining service period for recognition of unrecognized compensation cost	2 years 10 months 24 days
Research and development
Stock option plan
Share-based compensation expense	$ 8,663	8,967
Selling, general and administrative
Stock option plan
Share-based compensation expense	$ 9,397	$ 9,411

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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