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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Cash flows from operating activities    
Net Income (Loss) $ 866,562 $ (91,576)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:    
Depreciation and amortization 7,221 55,395
Non-cash operating lease expense 1,790 1,792
Non-cash royalty revenue related to sale of future royalties (32,974) (25,228)
Non-cash interest expense on liability related to sale of future royalties 49,661 50,064
Change in valuation of contingent consideration (800) (100)
Loss on sale of fixed assets 77  
Unrealized loss (gain) on ClearPoint Equity Investments 3,122 (9)
Unrealized gain on ClearPoint convertible debt security   (166)
Unrealized gain on marketable securities - equity investments (774) (710)
Disposal of asset   544
Deferred income taxes 2 (1)
Amortization of discounts on investments, net (2,313) (3,697)
Amortization of debt issuance costs 299 296
Share-based compensation expense 18,060 18,378
Unrealized foreign currency transaction losses, net 2,251 269
Changes in operating assets and liabilities:    
Inventory, net 2,191 120
Prepaid expenses and other current assets (16,429) 93,904
Trade and royalty receivables, net (47,792) (39,500)
Deposits and other assets (611) 11,192
Accounts payable and accrued expenses 18,502 (5,389)
Other liabilities (458) 5,984
Deferred revenue 7,200 (801)
Payments on contingent consideration (4,684)  
Net cash provided by operating activities 870,103 70,761
Cash flows from investing activities    
Purchases of fixed assets (1,724) (9,588)
Proceeds from sale of fixed assets 70  
Purchases of marketable securities - available for sale (322,335) (104,373)
Purchases of marketable securities - equity investments (5,209) (9,065)
Sale and redemption of marketable securities- available for sale 136,750 61,650
Sale and redemption of marketable securities - equity investments 8,896 1,207
Acquisition of product rights and licenses (808) (54,763)
Net cash used in investing activities (184,360) (114,932)
Cash flows from financing activities    
Proceeds from exercise of options 15,751 2,030
Payments on contingent consideration obligation (6,341)  
Payment of finance lease principal   (1,490)
Net cash provided by financing activities 9,410 540
Effect of exchange rate changes on cash 5,393 (2,030)
Net increase (decrease) in cash and cash equivalents 700,546 (45,661)
Cash and cash equivalents, and restricted cash beginning of period 795,316 610,284
Cash and cash equivalents, and restricted cash end of period 1,495,862 564,623
Supplemental disclosure of cash information    
Cash paid for interest 2,156 3,666
Cash paid for income taxes 3,040 2,042
Supplemental disclosure of non-cash investing and financing activity    
Unrealized loss on marketable securities, net of tax (88) (444)
Right-of-use assets obtained in exchange for operating lease obligations 850 1,723
Acquisition of product rights and licenses 2,185 2,296
Fixed asset additions through tenant improvement allowance $ 374  
Milestone payable   $ 2,500