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Intangible assets and goodwill - (Tables) | 6 Months Ended
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Jun. 30, 2025
Goodwill and Intangible Assets Disclosure [Abstract] |
Schedule of definite lived intangible assets | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | Ending Balance at | ​ | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | Ending Balance at
Definite-lived | ​ | ​ | December 31, | ​ | ​ | ​ | ​ | ​ | currency | ​ | ​ | June 30,
intangible assets, gross |  | ​ | 2024 |  | ​ | Additions |  | ​ | translation | ​ | ​ | 2025
Waylivra | ​ | ​ | 12,397 | ​ | ​ | 3,293 | ​ | ​ | 1,705 | ​ | ​ | 17,395
Tegsedi | ​ | ​ | 18,249 | ​ | ​ | 2,021 | ​ | ​ | 2,361 | ​ | ​ | 22,631
Kebilidi | ​ | ​ | 10,731 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 10,731
Upstaza | ​ | ​ | 106,937 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 106,937
Sephience | ​ | ​ | — | ​ | ​ | 25,000 | ​ | ​ | — | ​ | ​ | 25,000
Total definite-lived intangibles, gross | ​ | $ | 148,314 | ​ | $ | 30,314 | ​ | $ | 4,066 | ​ | $ | 182,694
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | Ending Balance at | ​ | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | Ending Balance at
Definite-lived | ​ | ​ | December 31, | ​ | ​ | ​ | ​ | ​ | currency | ​ | ​ | June 30,
intangible assets, accumulated amortization |  | ​ | 2024 |  | ​ | Amortization |  | ​ | translation |  | ​ | 2025
Waylivra | ​ | ​ | (5,273) | ​ | ​ | (1,187) | ​ | ​ | (720) | ​ | ​ | (7,180)
Tegsedi | ​ | ​ | (5,609) | ​ | ​ | (1,735) | ​ | ​ | (789) | ​ | ​ | (8,133)
Kebilidi | ​ | ​ | (112) | ​ | ​ | (447) | ​ | ​ | — | ​ | ​ | (559)
Upstaza | ​ | ​ | (18,526) | ​ | ​ | (4,456) | ​ | ​ | — | ​ | ​ | (22,982)
Sephience | ​ | ​ | — | ​ | ​ | (34) | ​ | ​ | — | ​ | ​ | (34)
Total definite-lived intangibles, accumulated amortization | ​ | $ | (29,520) | ​ | $ | (7,859) | ​ | $ | (1,509) | ​ | $ | (38,888)
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total definite-lived intangibles, net | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | $ | 143,806
​
Schedule of estimated future amortization of intangible assets | ​
​ | ​ | ​ | ​
​ |  | As of June 30, 2025
2025 | ​ | $ | 9,382
2026 | ​ |  | 18,751
2027 | ​ |  | 18,751
2028 | ​ |  | 18,751
2029 and thereafter | ​ |  | 78,171
Total | ​ | $ | 143,806

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- Definition Tabular disclosure of assets, excluding financial assets and goodwill, lacking physical substance with a finite life, by either major class or business segment. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Name Accounting Standards Codification -Section 55 -Paragraph 40 -SubTopic 30 -Topic 350 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482640/350-30-55-40 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 350 -SubTopic 30 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482665/350-30-50-2 + Details
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