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Intangible assets and goodwill - (Tables)

6 Months Ended

Jun. 30, 2025

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of definite lived intangible assets

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Ending Balance at

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Foreign

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Ending Balance at

Definite-lived

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December 31,

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currency

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​

June 30,

intangible assets, gross

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2024

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Additions

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translation

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​

2025

Waylivra

​

​

12,397

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​

3,293

​

​

1,705

​

​

17,395

Tegsedi

​

​

18,249

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​

2,021

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​

2,361

​

​

22,631

Kebilidi

​

​

10,731

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​

—

​

​

—

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​

10,731

Upstaza

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​

106,937

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​

—

​

​

—

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​

106,937

Sephience

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​

—

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25,000

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​

—

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​

25,000

Total definite-lived intangibles, gross

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$

148,314

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$

30,314

​

$

4,066

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$

182,694

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Ending Balance at

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Foreign

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Ending Balance at

Definite-lived

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December 31,

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currency

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June 30,

intangible assets, accumulated amortization

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2024

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Amortization

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translation

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2025

Waylivra

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​

(5,273)

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​

(1,187)

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(720)

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​

(7,180)

Tegsedi

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​

(5,609)

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​

(1,735)

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​

(789)

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​

(8,133)

Kebilidi

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​

(112)

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​

(447)

​

​

—

​

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(559)

Upstaza

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​

(18,526)

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​

(4,456)

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​

—

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(22,982)

Sephience

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​

—

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(34)

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​

—

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(34)

Total definite-lived intangibles, accumulated amortization

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$

(29,520)

​

$

(7,859)

​

$

(1,509)

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$

(38,888)

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​

​

​

​

​

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Total definite-lived intangibles, net

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$

143,806

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Schedule of estimated future amortization of intangible assets

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​	​	​	​
​		As of June 30, 2025
2025	​	$	9,382
2026	​		18,751
2027	​		18,751
2028	​		18,751
2029 and thereafter	​		78,171
Total	​	$	143,806

X

- References

No definition available.

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X

- Definition

Tabular disclosure of assets, excluding financial assets and goodwill, lacking physical substance with a finite life, by either major class or business segment.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Name Accounting Standards Codification
-Section 55
-Paragraph 40
-SubTopic 30
-Topic 350
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482640/350-30-55-40

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482665/350-30-50-2

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- Definition

Tabular disclosure of the amount of amortization expense expected to be recorded in succeeding fiscal years for finite-lived intangible assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Name Accounting Standards Codification
-Section 55
-Paragraph 40
-SubTopic 30
-Topic 350
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482640/350-30-55-40

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)(3)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482665/350-30-50-2

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