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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Stock option plan
Share-based compensation expense	$ 18,543	$ 19,243	$ 36,603	$ 37,621
Research and development
Stock option plan
Share-based compensation expense	9,030	9,428	17,693	18,395
Selling, general and administrative
Stock option plan
Share-based compensation expense	$ 9,513	$ 9,815	$ 18,910	$ 19,226

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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