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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2025
Jun. 30, 2024
Cash flows from operating activities    
Net Income (Loss) $ 801,713 $ (190,755)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:    
Depreciation and amortization 14,804 62,413
Non-cash operating lease expense 3,634 4,472
Non-cash royalty revenue related to sale of future royalties (85,099) (73,349)
Non-cash interest expense on liability related to sale of future royalties 99,329 102,340
Change in valuation of contingent consideration (800) 5,000
Tangible asset impairment 99 168
Loss on sale of fixed assets 77 3,772
Gain on lease terminations   (2,179)
Unrealized loss on ClearPoint Equity Investments 3,078 1,252
Unrealized loss on ClearPoint convertible debt security   1,931
Unrealized gain on marketable securities - equity investments (1,538) (1,111)
Deferred income taxes   1
Amortization of discounts on investments, net (6,869) (6,993)
Amortization of debt issuance costs 601 591
Share-based compensation expense 36,603 37,621
Unrealized foreign currency transaction losses (gains), net 4,939 (198)
Changes in operating assets and liabilities:    
Inventory, net (8,591) (1,816)
Prepaid expenses and other current assets (12,197) 99,791
Trade and royalty receivables, net (25,891) (31,310)
Deposits and other assets (827) 10,062
Accounts payable and accrued expenses 6,864 (18,702)
Other liabilities (17,320) (2,892)
Deferred revenue 3,845 (801)
Payments on contingent consideration (4,684)  
Net cash provided by (used in) operating activities 811,770 (692)
Cash flows from investing activities    
Purchases of fixed assets (3,041) (2,213)
Proceeds from sale of fixed assets 70 28,038
Purchases of marketable securities- available for sale (847,164) (291,734)
Purchases of marketable securities- equity investments (17,029) (17,406)
Sale and redemption of marketable securities- available for sale 247,151 136,650
Sale and redemption of marketable securities- equity investments 17,129 20,573
Acquisition of product rights and licenses (3,485) (54,763)
Net cash used in investing activities (606,369) (180,855)
Cash flows from financing activities    
Proceeds from exercise of options 16,885 4,747
Proceeds from employee stock purchase plan 2,827 1,973
Proceeds from sale of future royalties   241,792
Payments on contingent consideration obligation (6,341)  
Payment of finance lease principal   (1,490)
Net cash provided by financing activities 13,371 247,022
Effect of exchange rate changes on cash 18,981 (7,217)
Net increase in cash and cash equivalents 237,753 58,258
Cash and cash equivalents, and restricted cash beginning of period 795,316 610,284
Cash and cash equivalents, and restricted cash end of period 1,033,069 668,542
Supplemental disclosure of cash information    
Cash paid for interest 2,156 3,666
Cash paid for income taxes 39,188 6,117
Supplemental disclosure of non-cash investing and financing activity    
Unrealized loss on marketable securities, net of tax (274) (556)
Right-of-use assets obtained in exchange for operating lease obligations 850 1,723
Acquisition of product rights and licenses 2,285 3,105
Fixed asset additions through tenant improvement allowance 385 16,739
Milestone payable $ 25,150 $ 37,500