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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended
	Jan. 31, 2025 USD ($)	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)	Jun. 30, 2025 USD ($) product	Jun. 30, 2024 USD ($)	Dec. 31, 2024 USD ($)	Nov. 30, 2011 USD ($)
Revenue recognition
Number of approved products \| product				2
Remaining potential milestones that can be achieved						$ 150,000
Revenue		$ 178,875	$ 186,704	$ 1,354,971	$ 396,822
Deferred revenue		9,760		9,760		$ 5,505
Collaboration and license revenue
Revenue recognition
Revenue		2,941		989,172
Royalty revenue
Revenue recognition
Revenue		57,605	53,183	$ 94,044	84,337
SMA License Agreement
Revenue recognition
Number of approved products \| product				1
SMA License Agreement \| Collaboration and license revenue
Revenue recognition
Revenue			0		0
SMA License Agreement \| Royalty revenue
Revenue recognition
Revenue		57,600	$ 53,200	$ 94,000	$ 84,300
License and Collaboration Agreement
Revenue recognition
Refund of revenue related to prior collaboration arrangements				3,500
License and Collaboration Agreement \| Novartis
Revenue recognition
Cash proceeds from upfront payment on collaboration agreement	$ 1,000,000
Percentage share of the income (loss) generated on U.S. sales	40.00%
Deferred revenue		7,300		7,300
License and Collaboration Agreement \| Novartis \| Collaboration and license revenue
Revenue recognition
Revenue		2,900		992,700
Research And Development Event Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved		0		0
Sales Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved		$ 150,000		$ 150,000
Maximum \| License and Collaboration Agreement \| Novartis
Revenue recognition
Potential future proceeds contingent on achievement of developmental, regulatory and sales milestones and tiered royalties	$ 1,900,000
Maximum \| Research And Development Event Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved							$ 135,000
Maximum \| Sales Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved							$ 325,000