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Intangible assets and goodwill - Definite-lived Intangibles (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended
Jun. 30, 2025
Jun. 30, 2025
Jun. 30, 2024
Jun. 30, 2025
Jun. 30, 2024
Dec. 31, 2024
Definite-lived intangible assets            
Accrued royalties $ 5,493 $ 5,493   $ 5,493   $ 8,953
Milestone Payable 25,150 25,150 $ 37,500 25,150 $ 37,500 $ 11,025
Definite-lived intangibles            
Amortization   (4,061) (2,865) (7,859) (54,395)  
Total definite-lived intangibles, net $ 143,806 $ 143,806   $ 143,806    
Weighted Average            
Definite-lived intangible assets            
Remaining amortization period 8 years 9 months 18 days 8 years 9 months 18 days   8 years 9 months 18 days    
Akcea | Tegsedi            
Definite-lived intangible assets            
Royalty payments       $ 2,000    
Akcea | Tegsedi | Accounts payable and accrued expenses            
Definite-lived intangible assets            
Accrued royalties $ 900 $ 900   900    
Akcea | Waylivra            
Definite-lived intangible assets            
Royalty payments       3,300    
Akcea | Waylivra | Accounts payable and accrued expenses            
Definite-lived intangible assets            
Accrued royalties 1,400 1,400   1,400    
Censa | Censa Merger Agreement            
Definite-lived intangible assets            
Milestone obligation payments recorded 25,000          
Milestone Payable 25,000 25,000   25,000    
Definite-lived intangible assets            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross       148,314    
Additions       30,314    
Foreign currency translation       4,066    
Ending balance - Definite-lived assets, Gross 182,694 182,694   182,694    
Beginning balance - Accumulated amortization       (29,520)    
Amortization   (4,100) $ (2,900) (7,859) $ (54,400)  
Foreign currency translation - Accumulated amortization       (1,509)    
Ending balance - Accumulated amortization (38,888) (38,888)   (38,888)    
Total definite-lived intangibles, net 143,806 143,806   143,806    
Definite-lived intangible assets | Tegsedi            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross       18,249    
Additions       2,021    
Foreign currency translation       2,361    
Ending balance - Definite-lived assets, Gross 22,631 22,631   22,631    
Beginning balance - Accumulated amortization       (5,609)    
Amortization       (1,735)    
Foreign currency translation - Accumulated amortization       (789)    
Ending balance - Accumulated amortization (8,133) (8,133)   (8,133)    
Definite-lived intangible assets | Waylivra            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross       12,397    
Additions       3,293    
Foreign currency translation       1,705    
Ending balance - Definite-lived assets, Gross 17,395 17,395   17,395    
Beginning balance - Accumulated amortization       (5,273)    
Amortization       (1,187)    
Foreign currency translation - Accumulated amortization       (720)    
Ending balance - Accumulated amortization (7,180) (7,180)   (7,180)    
Definite-lived intangible assets | Kebilidi            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross       10,731    
Ending balance - Definite-lived assets, Gross 10,731 10,731   10,731    
Beginning balance - Accumulated amortization       (112)    
Amortization       (447)    
Ending balance - Accumulated amortization (559) (559)   (559)    
Definite-lived intangible assets | Upstaza            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross       106,937    
Ending balance - Definite-lived assets, Gross 106,937 106,937   106,937    
Beginning balance - Accumulated amortization       (18,526)    
Amortization       (4,456)    
Ending balance - Accumulated amortization (22,982) (22,982)   (22,982)    
Definite-lived intangible assets | Sephience            
Definite-lived intangibles            
Additions       25,000    
Ending balance - Definite-lived assets, Gross 25,000 25,000   25,000    
Amortization       (34)    
Ending balance - Accumulated amortization $ (34) $ (34)   $ (34)