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Segment information - Significant Expenses by Segment (Details)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2025
USD ($)
segment
Jun. 30, 2024
USD ($)
segment
Jun. 30, 2025
USD ($)
segment
Jun. 30, 2024
USD ($)
segment
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Number of Operating Segments | segment 1 1 1 1
Total revenues $ 178,875 $ 186,704 $ 1,354,971 $ 396,822
Net (loss) income attributable to common stockholders (64,849) (99,179) 801,713 (190,755)
Income tax (benefit) expense (6,203) 13,446 57,063 20,326
Amortization 4,061 2,865 7,859 54,395
Operating segments | Life Science        
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Total revenues 178,875 186,704 1,354,971 396,822
Cost of product, collaboration and license sales 8,093 4,477 15,800 9,671
Program spend 49,705 52,959 97,863 101,323
Employee costs 65,593 59,558 133,292 123,555
Manufacturing costs 19,519 12,325 34,470 30,406
Administrative costs 17,896 18,623 36,310 35,495
Occupancy costs 6,643 9,588 13,825 19,481
Milestones   15,000   15,000
Other segment items 76,275 113,353 221,698 252,646
Net (loss) income attributable to common stockholders (64,849) (99,179) 801,713 (190,755)
Interest income (20,991) (10,494) (38,236) (21,434)
Interest expense 51,349 53,984 102,686 105,758
Income tax (benefit) expense (6,203) 13,446 57,063 20,326
Depreciation 3,573 4,155 7,031 8,021
Amortization 4,061 2,865 7,859 54,395
All other 44,486 49,397 85,295 85,580
Total other segment items $ 76,275 $ 113,353 $ 221,698 $ 252,646