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Intangible assets and goodwill - Definite-lived Intangibles (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Jul. 31, 2025 | Jun. 30, 2025 | Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024 | Aug. 31, 2025 | Aug. 05, 2025 | Dec. 31, 2024
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Accrued royalties |  |  | $ 5,146 |  | $ 5,146 |  |  |  | $ 8,953
Milestone Payable |  |  | 32,500 | $ 50,000 | 32,500 | $ 50,000 |  |  | $ 11,025
Definite-lived intangibles |  |  |  |  |  |  |  |  |
Amortization |  |  | (7,534) | (3,036) | (15,393) | (57,431) |  |  |
Total definite-lived intangibles, net |  |  | $ 396,466 |  | $ 396,466 |  |  |  |
Weighted Average |  |  |  |  |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Remaining amortization period |  |  | 12 years 2 months 12 days |  | 12 years 2 months 12 days |  |  |  |
Rights Satisfaction Agreement |  |  |  |  |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Maximum Upfront Consideration Agreed To Be Paid |  |  |  |  |  |  | $ 225,100 | $ 250,000 |
Akcea | Tegsedi |  |  |  |  |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Royalty payments |  |  |  |  | $ 3,400 |  |  |  |
Akcea | Tegsedi | Accounts payable and accrued expenses |  |  |  |  |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Accrued royalties |  |  | $ 1,200 |  | 1,200 |  |  |  |
Akcea | Waylivra |  |  |  |  |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Royalty payments |  |  |  |  | 4,300 |  |  |  |
Akcea | Waylivra | Accounts payable and accrued expenses |  |  |  |  |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Accrued royalties |  |  | 900 |  | 900 |  |  |  |
Censa | Sephience |  |  |  |  |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Royalty payments |  |  |  |  | 200 |  |  |  |
Accrued royalties |  |  | 200 |  | 200 |  |  |  |
Censa | Censa Merger Agreement |  |  |  |  |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Milestone obligation payments recorded | $ 32,500 | $ 25,000 |  |  |  |  |  |  |
Milestone Payable | $ 32,500 |  | 32,500 |  | 32,500 |  |  |  |
Definite-lived intangible assets |  |  |  |  |  |  |  |  |
Definite-lived intangibles |  |  |  |  |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  |  |  | 148,314 |  |  |  |
Additions |  |  |  |  | 290,501 |  |  |  |
Foreign currency translation |  |  |  |  | 4,076 |  |  |  |
Ending balance - Definite-lived assets, Gross |  |  | 442,891 |  | 442,891 |  |  |  |
Beginning balance - Accumulated amortization |  |  |  |  | (29,520) |  |  |  |
Amortization |  |  | (7,500) | $ (3,000) | (15,393) | $ (57,400) |  |  |
Foreign currency translation - Accumulated amortization |  |  |  |  | (1,512) |  |  |  |
Ending balance - Accumulated amortization |  |  | (46,425) |  | (46,425) |  |  |  |
Total definite-lived intangibles, net |  |  | 396,466 |  | 396,466 |  |  |  |
Definite-lived intangible assets | Tegsedi |  |  |  |  |  |  |  |  |
Definite-lived intangibles |  |  |  |  |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  |  |  | 18,249 |  |  |  |
Additions |  |  |  |  | 3,448 |  |  |  |
Foreign currency translation |  |  |  |  | 2,367 |  |  |  |
Ending balance - Definite-lived assets, Gross |  |  | 24,064 |  | 24,064 |  |  |  |
Beginning balance - Accumulated amortization |  |  |  |  | (5,609) |  |  |  |
Amortization |  |  |  |  | (2,774) |  |  |  |
Foreign currency translation - Accumulated amortization |  |  |  |  | (791) |  |  |  |
Ending balance - Accumulated amortization |  |  | (9,174) |  | (9,174) |  |  |  |
Definite-lived intangible assets | Waylivra |  |  |  |  |  |  |  |  |
Definite-lived intangibles |  |  |  |  |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  |  |  | 12,397 |  |  |  |
Additions |  |  |  |  | 4,290 |  |  |  |
Foreign currency translation |  |  |  |  | 1,709 |  |  |  |
Ending balance - Definite-lived assets, Gross |  |  | 18,396 |  | 18,396 |  |  |  |
Beginning balance - Accumulated amortization |  |  |  |  | (5,273) |  |  |  |
Amortization |  |  |  |  | (1,921) |  |  |  |
Foreign currency translation - Accumulated amortization |  |  |  |  | (721) |  |  |  |
Ending balance - Accumulated amortization |  |  | (7,915) |  | (7,915) |  |  |  |
Definite-lived intangible assets | Kebilidi |  |  |  |  |  |  |  |  |
Definite-lived intangibles |  |  |  |  |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  |  |  | 10,731 |  |  |  |
Ending balance - Definite-lived assets, Gross |  |  | 10,731 |  | 10,731 |  |  |  |
Beginning balance - Accumulated amortization |  |  |  |  | (112) |  |  |  |
Amortization |  |  |  |  | (671) |  |  |  |
Ending balance - Accumulated amortization |  |  | (783) |  | (783) |  |  |  |
Definite-lived intangible assets | Upstaza |  |  |  |  |  |  |  |  |
Definite-lived intangibles |  |  |  |  |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  |  |  | 106,937 |  |  |  |
Ending balance - Definite-lived assets, Gross |  |  | 106,937 |  | 106,937 |  |  |  |
Beginning balance - Accumulated amortization |  |  |  |  | (18,526) |  |  |  |
Amortization |  |  |  |  | (6,684) |  |  |  |
Ending balance - Accumulated amortization |  |  | (25,210) |  | (25,210) |  |  |  |
Definite-lived intangible assets | Sephience |  |  |  |  |  |  |  |  |
Definite-lived intangibles |  |  |  |  |  |  |  |  |
Additions |  |  |  |  | 282,763 |  |  |  |
Ending balance - Definite-lived assets, Gross |  |  | 282,763 |  | 282,763 |  |  |  |
Amortization |  |  |  |  | (3,343) |  |  |  |
Ending balance - Accumulated amortization |  |  | $ (3,343) |  | $ (3,343) |  |  |  |

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