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Accounts payable and accrued expenses - Components (Details) - USD ($) $ in Thousands | Sep. 30, 2025 | Dec. 31, 2024 | Sep. 30, 2024
--- | --- | --- | ---
Accounts payable and accrued expenses |  |  |
Employee compensation, benefits, and related accruals | $ 49,466 | $ 61,575 |
Income tax payable | 2,927 | 4,701 |
Consulting and contracted research | 19,961 | 19,909 |
Sales allowance | 55,302 | 58,644 |
Sales rebates | 83,850 | 101,613 |
Royalties | 5,146 | 8,953 |
Accounts payable | 36,617 | 17,274 |
Milestone Payable | 32,500 | 11,025 | $ 50,000
Other | 17,372 | 20,598 |
Accounts payable and accrued expenses | $ 303,141 | $ 304,292 |

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