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Intangible assets and goodwill - (Tables) | 9 Months Ended
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Sep. 30, 2025
Goodwill and Intangible Assets Disclosure [Abstract] |
Schedule of definite lived intangible assets | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | Ending Balance at | ​ | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | Ending Balance at
Definite-lived | ​ | ​ | December 31, | ​ | ​ | ​ | ​ | ​ | currency | ​ | ​ | September 30,
intangible assets, gross |  | ​ | 2024 |  | ​ | Additions |  | ​ | translation | ​ | ​ | 2025
Waylivra | ​ | ​ | 12,397 | ​ | ​ | 4,290 | ​ | ​ | 1,709 | ​ | ​ | 18,396
Tegsedi | ​ | ​ | 18,249 | ​ | ​ | 3,448 | ​ | ​ | 2,367 | ​ | ​ | 24,064
Kebilidi | ​ | ​ | 10,731 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 10,731
Upstaza | ​ | ​ | 106,937 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 106,937
Sephience | ​ | ​ | — | ​ | ​ | 282,763 | ​ | ​ | — | ​ | ​ | 282,763
Total definite-lived intangibles, gross | ​ | $ | 148,314 | ​ | $ | 290,501 | ​ | $ | 4,076 | ​ | $ | 442,891
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | Ending Balance at | ​ | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | Ending Balance at
Definite-lived | ​ | ​ | December 31, | ​ | ​ | ​ | ​ | ​ | currency | ​ | ​ | September 30,
intangible assets, accumulated amortization |  | ​ | 2024 |  | ​ | Amortization |  | ​ | translation |  | ​ | 2025
Waylivra | ​ | ​ | (5,273) | ​ | ​ | (1,921) | ​ | ​ | (721) | ​ | ​ | (7,915)
Tegsedi | ​ | ​ | (5,609) | ​ | ​ | (2,774) | ​ | ​ | (791) | ​ | ​ | (9,174)
Kebilidi | ​ | ​ | (112) | ​ | ​ | (671) | ​ | ​ | — | ​ | ​ | (783)
Upstaza | ​ | ​ | (18,526) | ​ | ​ | (6,684) | ​ | ​ | — | ​ | ​ | (25,210)
Sephience | ​ | ​ | — | ​ | ​ | (3,343) | ​ | ​ | — | ​ | ​ | (3,343)
Total definite-lived intangibles, accumulated amortization | ​ | $ | (29,520) | ​ | $ | (15,393) | ​ | $ | (1,512) | ​ | $ | (46,425)
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total definite-lived intangibles, net | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | $ | 396,466
​
Schedule of estimated future amortization of intangible assets | ​
​ | ​ | ​ | ​
​ |  | As of September 30, 2025
2025 | ​ | $ | 9,280
2026 | ​ |  | 37,098
2027 | ​ |  | 37,098
2028 | ​ |  | 37,098
2029 and thereafter | ​ |  | 275,892
Total | ​ | $ | 396,466

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- Definition Tabular disclosure of assets, excluding financial assets and goodwill, lacking physical substance with a finite life, by either major class or business segment. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Name Accounting Standards Codification -Section 55 -Paragraph 40 -SubTopic 30 -Topic 350 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482640/350-30-55-40 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 350 -SubTopic 30 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482665/350-30-50-2 + Details
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