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v3.25.3

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Cash flows from operating activities |  |
Net Income (Loss) | $ 817,609 | $ (297,409)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: |  |
Depreciation and amortization | 25,913 | 68,899
Non-cash operating lease expense | 5,635 | 6,272
Non-cash royalty revenue related to sale of future royalties | (149,160) | (128,877)
Non-cash interest expense on liability related to sale of future royalties | 149,305 | 155,039
Change in valuation of contingent consideration | (800) | 5,700
Tangible asset impairment | 518 | 1,486
Loss on sale of fixed assets | 130 | 4,298
Gain on lease terminations |  | (2,179)
Unrealized gain on ClearPoint Equity Investments | (5,734) | (3,954)
Unrealized loss on ClearPoint convertible debt security |  | 1,931
Unrealized gain on marketable securities - equity investments | (3,160) | (1,923)
Realized loss on ClearPoint convertible debt security |  | 622
Disposal of asset | 163 | 76
Deferred income taxes | (4) | (2)
Amortization of discounts on investments, net | (12,972) | (9,947)
Amortization of debt issuance costs | 906 | 891
Share-based compensation expense | 56,029 | 57,376
Unrealized foreign currency transaction losses (gains), net | 4,768 | (147)
Changes in operating assets and liabilities: |  |
Inventory, net | (27,117) | (4,922)
Prepaid expenses and other current assets | (13,876) | 107,957
Trade and royalty receivables, net | (32,365) | (39,029)
Deposits and other assets | 1,501 | 7,909
Accounts payable and accrued expenses | (36,341) | (417)
Other liabilities | (26,497) | (4,733)
Deferred revenue | (4,298) | (801)
Payments on contingent consideration | (4,684) | (1,800)
Net cash provided by (used in) operating activities | 745,469 | (77,684)
Cash flows from investing activities |  |
Purchases of fixed assets | (6,486) | (2,735)
Proceeds from sale of fixed assets | 70 | 28,056
Purchases of marketable securities- available for sale | (1,051,267) | (476,680)
Purchases of marketable securities- equity investments | (46,537) | (49,614)
Sale and redemption of marketable securities- available for sale | 424,351 | 290,836
Sale and redemption of marketable securities- equity investments | 40,112 | 41,624
Proceeds from settlement of Clearpoint convertible debt security |  | 10,000
Acquisition of product rights and licenses | (256,235) | (65,017)
Net cash used in investing activities | (895,992) | (223,530)
Cash flows from financing activities |  |
Proceeds from exercise of options | 33,715 | 5,320
Proceeds from employee stock purchase plan | 2,827 | 1,973
Proceeds from sale of future royalties |  | 241,792
Payments on contingent consideration obligation | (6,341) | (18,200)
Payment of finance lease principal | (1,611) | (1,490)
Net cash provided by financing activities | 28,590 | 229,395
Effect of exchange rate changes on cash | 12,917 | 1,325
Net decrease in cash and cash equivalents | (109,016) | (70,494)
Cash and cash equivalents, and restricted cash beginning of period | 795,316 | 610,284
Cash and cash equivalents, and restricted cash end of period | 686,300 | 539,790
Supplemental disclosure of cash information |  |
Cash paid for interest | 5,702 | 5,823
Cash paid for income taxes | 40,124 | 12,781
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized gain on marketable securities, net of tax | 402 | 2,204
Right-of-use assets obtained in exchange for operating lease obligations | 27,675 | 5,786
Acquisition of product rights and licenses | 2,221 | 2,346
Fixed asset additions through tenant improvement allowance | 766 | 18,675
Milestone payable | $ 32,500 | $ 50,000

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- Definition Amount of cash outflow for purchase of marketable security. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481830/320-10-45-11 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 13 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-13 + Details
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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References No definition available. + Details
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- Definition Amount of cash inflow from sale of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481830/320-10-45-11 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 9 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147481800/320-10-50-9 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-12 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-11 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 12 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-12 + Details
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- Definition Amount of cash inflow from exercise of option under share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-14 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2A -Subparagraph (a) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2A + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-14 + Details
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- Definition Amount of increase in right-of-use asset obtained in exchange for operating lease liability. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 842 -SubTopic 20 -Name Accounting Standards Codification -Section 55 -Paragraph 53 -Publisher FASB -URI https://asc.fasb.org/1943274/2147479589/842-20-55-53 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 842 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 4 -Subparagraph (g)(2) -Publisher FASB -URI https://asc.fasb.org/1943274/2147478964/842-20-50-4 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 28 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-28 + Details
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- Definition The charge against earnings resulting from the aggregate write down of tangible assets from their carrying value to their fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 360 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482099/360-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 205 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147483499/205-20-50-1 + Details
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