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Summary of significant accounting policies - Tangible asset impairment and losses (gains) on transactions, net (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Asset impairment and losses (gains) on transactions |  |  |  |
Gain (loss) on sale of fixed assets | $ (100) |  | $ (130) | $ (4,298)
Tangible asset impairment | $ 400 |  | $ 518 | 1,486
Gain on lease terminations |  |  |  | 2,179
South Plainfield, New Jersey office |  |  |  |
Asset impairment and losses (gains) on transactions |  |  |  |
Tangible asset impairment |  | $ 1,300 |  | 1,500
Early-stage gene therapy program assets |  |  |  |
Asset impairment and losses (gains) on transactions |  |  |  |
Gain (loss) on sale of fixed assets |  |  |  | 4,400
Other fixed assets |  |  |  |
Asset impairment and losses (gains) on transactions |  |  |  |
Gain (loss) on sale of fixed assets |  | $ 500 |  | $ 100

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