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Stock award plan - (Tables)

9 Months Ended

Sep. 30, 2025

Stock award plan

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2024		8,482,489	​	$	42.29				​	​
Granted		841,945	​	$	47.12				​	​
Exercised		(953,414)	​	$	35.75				​	​
Forfeited/Cancelled		(564,709)	​	$	53.91				​	​
Outstanding at September 30, 2025		7,806,311	​	$	42.77		5.66	years	​	$	151,190
Expected to vest at September 30, 2025		1,524,459	​	$	39.30		8.53	years	​	$	33,651
Exercisable at September 30, 2025		6,126,727	​	$	43.71		4.86	years	​	$	114,211

​

Schedule of assumptions used to estimate fair values of grants made on the date of grant

​

​	​	​	​
​		Nine months ended
​		September 30, 2025
Risk-free interest rate		3.81% - 4.44%
Expected volatility		55% - 56%
Expected term		5.5 years

Summary of information on the Company's restricted stock

​

​	​	​	​	​	​
​	​	Restricted Stock Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2024	​	3,527,575	​	$	33.39
Granted		1,615,305	​	​	47.16
PSUs with conditions satisfied		75,000	​	​	28.58
Vested	​	(1,201,681)	​	​	36.79
Forfeited		(227,396)	​	​	35.27
Unvested at September 30, 2025		3,788,803	​	$	37.98

Schedule of information about Performance-based restricted stock units

​

​	​	​	​	​	​	​
​	​	Performance-based Restricted Stock Units
​		Performance based		Market Conditions	​	Total
Total PSUs granted for which the performance or market conditions were not yet satisfied at December 31, 2024	​	175,000	​	31,250	​	206,250
PSUs with performance or market conditions satisfied during the period		(75,000)	​	—	​	(75,000)
Total PSUs granted for which the performance or market conditions were not yet satisfied at September 30, 2025		100,000	​	31,250	​	131,250

Schedule of share-based compensation expense recorded in the statement of operations

​

​	​	​	​	​	​	​	​	​	​	​	​	​
​	​	Three Months Ended September 30,					​	Nine Months Ended September 30,
​		2025			2024			2025			2024
Research and development	​	$	9,133	​	$	9,416	​	$	26,827	​	$	27,810
Selling, general and administrative	​		10,293	​		10,339	​		29,202	​		29,566
Total	​	$	19,426	​	$	19,755	​	$	56,029	​	$	57,376

​

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Tabular disclosure for performance based restricted stock units granted during the period.

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Section 50
-Subparagraph (c)
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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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