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Intangible assets and goodwill - (Tables)

9 Months Ended

Sep. 30, 2025

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of definite lived intangible assets


			Ending Balance at						Foreign			Ending Balance at
Definite-lived			December 31,						currency			September 30,
intangible assets, gross			2024			Additions			translation			2025
Waylivra			12,397			4,290			1,709			18,396
Tegsedi			18,249			3,448			2,367			24,064
Kebilidi			10,731			—			—			10,731
Upstaza			106,937			—			—			106,937
Sephience			—			282,763			—			282,763
Total definite-lived intangibles, gross		$	148,314		$	290,501		$	4,076		$	442,891


			Ending Balance at						Foreign			Ending Balance at
Definite-lived			December 31,						currency			September 30,
intangible assets, accumulated amortization			2024			Amortization			translation			2025
Waylivra			(5,273)			(1,921)			(721)			(7,915)
Tegsedi			(5,609)			(2,774)			(791)			(9,174)
Kebilidi			(112)			(671)			—			(783)
Upstaza			(18,526)			(6,684)			—			(25,210)
Sephience			—			(3,343)			—			(3,343)
Total definite-lived intangibles, accumulated amortization		$	(29,520)		$	(15,393)		$	(1,512)		$	(46,425)

Total definite-lived intangibles, net											$	396,466

Schedule of estimated future amortization of intangible assets


		As of September 30, 2025
2025		$	9,280
2026			37,098
2027			37,098
2028			37,098
2029 and thereafter			275,892
Total		$	396,466