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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Jun. 08, 2022
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Jun. 30, 2021
Dec. 31, 2020
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Dec. 31, 2024
Apr. 30, 2022
May 31, 2021
Jan. 31, 2020
Stock option plan                            
Share-based compensation expense             $ 19,426 $ 19,755 $ 56,029 $ 57,376        
Unrecognized compensation cost             137,200   $ 137,200          
Weighted average remaining service period for recognition of unrecognized compensation cost                 2 years 9 months 18 days          
Stock option                            
Stock option plan                            
Granted (in shares)                 841,945          
Options forfeited (in shares)                 564,709          
Expected dividend yield (as a percent)                 0.00%          
Weighted average grant date fair value (in dollars per share)                 $ 25.44          
Restricted stock units                            
Stock option plan                            
Granted (in shares)                 1,615,305          
Performance-based restricted stock units (PSUs)                            
Stock option plan                            
Share-based compensation expense             100   $ 500          
Performance-based restricted stock units (PSUs) | Chief Executive Officer                            
Stock option plan                            
Granted (in shares)   25,000 150,000           131,250   206,250      
Share-based compensation expense             1,000   $ 1,000          
Performance period   5 years 2 years                      
PSUs with performance or market conditions satisfied during the period                 75,000          
Employee Stock Purchase Plan                            
Stock option plan                            
Number of shares authorized (in shares)         2,000,000               1,000,000  
Award requisite service period         6 months                  
Purchase price of common stock, percent         85.00%                  
Employee stock purchase plan, voting percentage limit         5.00%                  
Share-based compensation expense             $ 600   $ 1,600          
Amended 2013 LTIP                            
Stock option plan                            
Number of shares available for issuance             5,204,816   5,204,816          
Number of additional shares authorized (in shares) 8,475,000                          
Amended 2013 LTIP | Maximum                            
Stock option plan                            
Number of shares authorized (in shares) 16,724,212                          
2020 Inducement Stock Incentive Plan | Common stock                            
Stock option plan                            
Number of shares available for issuance             1,802,161   1,802,161          
Number of additional shares authorized (in shares)       1,700,000   1,000,000                
2020 Inducement Stock Incentive Plan | Common stock | Maximum                            
Stock option plan                            
Number of shares authorized (in shares)                       1,300,000   1,000,000
2020 Inducement Stock Incentive Plan | Stock option                            
Stock option plan                            
Granted (in shares)                 51,200          
Stockholder's specified ownership percentage             10.00%   10.00%          
Vesting period                 4 years          
2020 Inducement Stock Incentive Plan | Stock option | Minimum                            
Stock option plan                            
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date             100.00%   100.00%          
2020 Inducement Stock Incentive Plan | Stock option | Maximum                            
Stock option plan                            
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date             110.00%   110.00%          
Expiration period                 10 years          
2020 Inducement Stock Incentive Plan | Restricted stock units                            
Stock option plan                            
Granted (in shares)                 107,050