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Stock award plan - Share-based compensation expense (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Stock option plan        
Share-based compensation expense $ 19,426 $ 19,755 $ 56,029 $ 57,376
Research and development        
Stock option plan        
Share-based compensation expense 9,133 9,416 26,827 27,810
Selling, general and administrative        
Stock option plan        
Share-based compensation expense $ 10,293 $ 10,339 $ 29,202 $ 29,566