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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
REVENUES:      
Total revenues $ 1,170,947 $ 1,094,274 $ 903,374
EXPENSES:      
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below) 180,385 176,420 154,748
Research and development 512,833 425,406 412,889
Selling, general and administrative 599,449 526,408 421,578
Amortization of acquired intangible assets 40,358 65,168 62,059
Restructuring expense 13,401    
Total expenses 1,346,426 1,193,402 1,051,274
OPERATING LOSS (175,479) (99,128) (147,900)
OTHER (EXPENSE) INCOME, NET:      
Interest income 13,976 9,238 4,649
Interest expense (13,601) (15,437) (12,008)
Change in the fair value of contingent consideration (22,800) (19,600) 21,600
Other income (expense), net 848 (2,040) (9,615)
Total other (expense) income, net (21,577) (27,839) 4,626
LOSS BEFORE INCOME TAXES (197,056) (126,967) (143,274)
INCOME TAX (BENEFIT) PROVISION (436) 12,344 14,671
NET LOSS $ (196,620) $ (139,311) $ (157,945)
LOSS PER ORDINARY SHARE:      
Basic and diluted (in dollars loss per ordinary share) $ (1.25) $ (0.90) $ (1.03)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:      
Basic and diluted (in shares) 157,051 155,112 153,415
COMPREHENSIVE LOSS:      
Net loss $ (196,620) $ (139,311) $ (157,945)
Holding gain (loss), net of a tax provision (benefit) of $426, $159, $(295), respectively 1,464 512 (518)
COMPREHENSIVE LOSS (195,156) (138,799) (158,463)
Manufacturing and royalty revenues      
REVENUES:      
Total revenues 447,882 526,675 505,308
Product sales, net      
REVENUES:      
Total revenues 524,499 450,334 362,834
Research and development revenue      
REVENUES:      
Total revenues 52,816 68,895 7,232
License revenue      
REVENUES:      
Total revenues $ 145,750 $ 48,370 $ 28,000