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Share-based Compensation (Tables)

12 Months Ended

Dec. 31, 2019

Schedule of Share-based Compensation Expense

The following table presents share‑based compensation expense included in the Company’s consolidated statements of operations and comprehensive loss:

		Year Ended December 31,
(In thousands)		2019				2018				2017
Cost of goods manufactured and sold		$	9,948			$	9,174			$	7,596
Research and development			29,924				32,943				22,635
Selling, general and administrative			61,105				63,240				53,686
Total share-based compensation expense		$	100,977			$	105,357			$	83,917

Schedule of Stock Option Activity

A summary of stock option activity is presented in the following table:

		Number of				Weighted Average
		Shares				Exercise Price
Outstanding, January 1, 2019			14,852,457			$	40.48
Granted			3,812,103			$	31.49
Exercised			(1,515,957	)		$	12.55
Expired			(1,104,967	)		$	48.42
Forfeited			(807,791	)		$	42.32
Outstanding, December 31, 2019			15,235,845			$	40.34
Exercisable, December 31, 2019			9,874,065			$	39.15

Time-vested RSUs

Summary of RSU Activity

A summary of time‑vested RSU activity is presented in the following table:

						Weighted Average
		Number of Shares				Grant Date Fair Value
Unvested, January 1, 2019			2,266,286			$	55.32
Granted			2,826,092			$	30.47
Vested			(791,484	)		$	53.62
Forfeited			(556,094	)		$	41.44
Unvested, December 31, 2019			3,744,800			$	38.99

Performance-based RSUs

Summary of RSU Activity

A summary of performance-based RSU activity is presented in the following table:

						Weighted Average
		Number of Shares				Grant Date Fair Value
Unvested, January 1, 2019			626,168			$	54.75
Granted			—			$	—
Forfeited			(81,000	)		$	54.77
Vested			(1,614	)		$	48.48
Unvested, December 31, 2019			543,554			$	54.75

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