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Revenue from Contracts with Customers - Additional Information (Details) $ in Thousands	1 Months Ended					3 Months Ended	12 Months Ended
	Dec. 31, 2019 USD ($)	Nov. 30, 2019 USD ($)	Oct. 31, 2019	Jun. 30, 2018 USD ($)	Nov. 30, 2017 USD ($) item	Dec. 31, 2019 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)
Disaggregation Of Revenue [Line Items]
Total revenues								$ 1,170,947	$ 1,094,274	$ 903,374
License revenue
Disaggregation Of Revenue [Line Items]
Total revenues								145,750	48,370	28,000
Research and development revenue
Disaggregation Of Revenue [Line Items]
Total revenues								$ 52,816	$ 68,895	$ 7,232
Biogen
Disaggregation Of Revenue [Line Items]
Up-front payment received					$ 28,000
Additional cash payment received		$ 150,000		$ 50,000
Number of initial performance obligations | item					4
Discount Rate (As a percent)					8.00%
Biogen | License revenue
Disaggregation Of Revenue [Line Items]
Total revenues		144,800		48,300	$ 27,000
Biogen | Research and development revenue
Disaggregation Of Revenue [Line Items]
Total revenues		5,200		1,500	900
Biogen | Research and development revenue | Forecast
Disaggregation Of Revenue [Line Items]
Additional revenue expected							$ 300
Biogen | Clinical Supply
Disaggregation Of Revenue [Line Items]
Total revenues				200	100
Biogen | License
Disaggregation Of Revenue [Line Items]
Total revenues	$ 5,000	$ 150,000		$ 50,000	$ 28,000
Percentage of net sales in royalty payment								15.00%
Biogen | License | Commercial Supply Agreements
Disaggregation Of Revenue [Line Items]
Maximum percentage of product supplies on net sales			100.00%
Milestone payments received						$ 5,800
Milestone payments receivable	$ 5,000					$ 5,000		$ 5,000

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=118956577&loc=SL49130543-203045

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=118956577&loc=SL49130545-203045

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