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Leases - Additional Information (Details)
$ in Thousands
 1 Months Ended 12 Months Ended
Nov. 18, 2019
ft²
Jan. 01, 2019
USD ($)
ft²
Option
Mar. 31, 2018
ft²
Dec. 31, 2019
USD ($)
lease
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Lessee Lease Description [Line Items]            
Area of real estate property     220,000      
Lessee operating lease term of option to extend     10 years      
Operating lease, existence of option to extend     true      
Number of additional operating leases | lease       2    
Weighted average incremental borrowing rate       4.73%    
Weighted average remaining lease term       4 years    
Operating lease, right-of-use asset | $   $ 20,100   $ 12,379    
Operating lease liabilities | $   $ 22,100   13,808    
Payments for operating leases | $       9,100    
Operating lease expense | $       $ 8,100 $ 10,800 $ 9,400
Lease, commencement date     Jan. 20, 2020      
Lease, expiration date     Jan. 31, 2035      
MASSACHUSETTS | Corporate office and administrative space expire in 2021            
Lessee Lease Description [Line Items]            
Area of real estate property   175,000        
Maximum number of option to extend lease term | Option   2        
Lessee operating lease term of option to extend   5 years        
Operating lease, existence of option to extend   true        
MASSACHUSETTS | Corporate office and administrative space expire in 2021 | Rodin Therapeutics, Inc.            
Lessee Lease Description [Line Items]            
Area of real estate property 5,300          
Lessee operating lease term of option to extend 1 year          
Operating lease, existence of option to extend true          
MASSACHUSETTS | Corporate office and administrative space expire in 2020            
Lessee Lease Description [Line Items]            
Area of real estate property   67,000        
Maximum number of option to extend lease term | Option   2        
Lessee operating lease term of option to extend   1 year        
Operating lease, existence of option to extend   true        
Ireland | Corporate office and administrative space expire in 2022            
Lessee Lease Description [Line Items]            
Area of real estate property   14,600        
Lessee operating lease term of option to extend   5 years        
Operating lease, existence of option to extend   true        
Washington | Corporate office and administrative space expire In 2029            
Lessee Lease Description [Line Items]            
Area of real estate property   7,000        
Lessee operating lease term of option to extend   5 years        
Operating lease, existence of option to extend   true