XML 65 R89.htm IDEA: XBRL DOCUMENT v3.19.3.a.u2
Collaborative Arrangements - Significant collaborative arrangements (Details)
1 Months Ended 12 Months Ended
Dec. 31, 2019
USD ($)
Nov. 30, 2019
USD ($)
Oct. 31, 2019
Jun. 30, 2018
USD ($)
Nov. 30, 2017
USD ($)
Dec. 31, 2019
USD ($)
Agreement
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Cash payments received           $ 1,170,947,000 $ 1,094,274,000 $ 903,374,000
VUMERITY                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Percentage of net sales in royalty payment           15.00%    
Maximum percentage of product supplies on net sales     100.00%          
Biogen                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Payment received upon the initiation of phase 3 clinical trial         $ 50,000,000.0      
Biogen | License                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Cash payments received $ 5,000,000.0 $ 150,000,000.0   $ 50,000,000.0 $ 28,000,000.0      
Percentage of net sales in royalty payment           15.00%    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Patent royalty rate (as a percent)           1.50%    
Know-how royalty rate resets (as a percent)           3.50%    
Period after the date of the first commercial sale of the product for license expiration           15 years    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Net sales of below $250.0 million                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Know-how royalty rate (as a percent)           3.50%    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Net sales between $250.0 million and 500.0 million                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Know-how royalty rate (as a percent)           5.50%    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Net sales greater than $500.0 million                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Know-how royalty rate (as a percent)           7.50%    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Minimum                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Royalty rate (as a percent)           5.00%    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Minimum | Net sales between $250.0 million and 500.0 million                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Aggregate worldwide net sales           $ 250,000,000    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Minimum | Net sales greater than $500.0 million                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Aggregate worldwide net sales           $ 500,000,000    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Maximum                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Royalty rate (as a percent)           9.00%    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Maximum | Net sales of below $250.0 million                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Aggregate worldwide net sales           $ 250,000,000    
License agreement | Janssen | INVEGA SUSTENNA/XEPLION | Maximum | Net sales between $250.0 million and 500.0 million                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Aggregate worldwide net sales           $ 500,000,000    
License agreement | Janssen | RISPERDAL CONSTA                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Royalty rate (as a percent)           2.50%    
Period after the date of the first commercial sale of the product for license expiration           15 years    
Number of license agreements | Agreement           2    
Notice period required to be given before termination of agreement           30 days    
Period for resolving default or breach after the receipt of notice for termination of agreement           90 days    
License agreement | Acorda                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Milestone payment entitled to be received upon the initiation of phase 3 clinical trial 1,000,000.0         $ 1,000,000.0    
Milestone payment entitled to be received upon the acceptance of NDA by the FDA 1,000,000.0         1,000,000.0    
Milestone payment entitled to be received upon the approval of NDA by the FDA 1,500,000         1,500,000    
Milestone payment entitled to be received upon the first commercial sale $ 1,500,000         $ 1,500,000    
License agreement | Acorda | AMPYRA/ FAMPYRA                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Royalty rate (as a percent)           10.00%    
Notice period required to be given before termination of agreement           90 days    
Manufacturing and supply agreement | Janssen | RISPERDAL CONSTA                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Period after the date of the first commercial sale of the product for license expiration           60 days    
Notice period required to be given before termination of agreement           6 months    
Manufacturing and supply agreement | Janssen | RISPERDAL CONSTA | Minimum                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Royalty rate (as a percent)           7.50%    
Royalty rate upon termination of manufacturing and supply agreement (as a percent)           2.50%    
Manufacturing and supply agreement | Janssen | RISPERDAL CONSTA | Maximum                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Royalty rate upon termination of manufacturing and supply agreement (as a percent)           5.00%    
Manufacturing and supply agreement | Acorda | AMPYRA/ FAMPYRA                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Royalty rate (as a percent)           8.00%    
Notice period required to be given before termination of agreement           12 months    
Manufacturing and supply agreement | Acorda | AMPYRA/ FAMPYRA | Maximum                
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                
Percentage of total annual requirement of product that can be obtained from second source manufacturer           25.00%