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Income Taxes - Additional Information (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2017
Dec. 31, 2018
Dec. 31, 2016
Income Taxes [Line Items]        
Tax expense from enactment of Tax Cuts and Jobs Act   $ 21,453    
Cumulative unremitted earnings of overseas subsidiaries $ 418,100      
Deferred tax asset in respect of accrued lease liability 4,300      
Deferred tax liability in respect of right to use asset 4,300      
Less: valuation allowance (242,059) (172,797) $ (219,093) $ (141,859)
Federal research and development credits 49,600      
State tax credits $ 18,000      
Minimum        
Income Taxes [Line Items]        
Period after loss carryforwards utilized that tax returns remain open to examination 3 years      
Maximum        
Income Taxes [Line Items]        
Period after loss carryforwards utilized that tax returns remain open to examination 4 years      
U.S. state        
Income Taxes [Line Items]        
Less: valuation allowance $ (17,300)      
Operating loss carryforwards 44,500      
U.S. state | Rodin Therapeutics, Inc.        
Income Taxes [Line Items]        
Operating loss carryforwards 43,300      
Federal research and development credits 400      
U.S. federal        
Income Taxes [Line Items]        
Tax expense from enactment of Tax Cuts and Jobs Act   $ 21,500    
Operating loss carryforwards 49,500      
U.S. federal | Rodin Therapeutics, Inc.        
Income Taxes [Line Items]        
Operating loss carryforwards 51,400      
Federal research and development credits 800      
Ireland        
Income Taxes [Line Items]        
Income taxes payable on repatriation of unremitted earnings 12,900      
Less: valuation allowance (224,800)      
Operating loss carryforwards $ 1,500,000