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Income Taxes - Schedule of Reconciliation of Statutory Tax Rate to Effective Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Reconciliation of effective income tax rate
Statutory tax rate (as a percent)	12.50%	12.50%	12.50%
Income tax provision at statutory rate	$ (24,632)	$ (15,871)	$ (17,909)
Change in valuation allowance	19,882	28,371	26,771
In-process R&D	10,824
Share-based compensation	6,287	1,163	(1,205)
Foreign rate differential	5,390	5,405	(682)
U.S. state income taxes, net of U.S. federal benefit	1,051	1,732	(558)
Foreign derived intangible income	(3,450)
Intercompany amounts	(1,125)	(751)	(5,041)
R&D credit	(8,846)	(7,698)	(9,326)
Federal tax law change	(8,111)
Federal tax law change			21,453
Irish rate differential	(146)	(2,350)	(2,675)
Impairment on equity method investment			1,662
Other permanent items	2,440	2,343	2,181
Total tax (benefit) provision	$ (436)	$ 12,344	$ 14,671
Effective tax rate (as a percent)	0.20%	(9.70%)	(10.20%)

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Amount of difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying domestic federal statutory income tax rates to pretax income (loss) from continuing operations, attributable to impairment on equity method investments.

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