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Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
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Jun. 30, 2021 | Jun. 30, 2020 | Jun. 30, 2021 | Jun. 30, 2020
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | $ 27,552 | $ 22,846 | $ 43,003 | $ 42,659
Cost of goods manufactured and sold |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | 2,683 | 2,015 | 4,861 | 3,980
Research and development |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | 7,131 | 6,478 | 11,194 | 12,638
Selling, general and administrative |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | $ 17,738 | $ 14,353 | $ 26,948 | $ 26,041

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