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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) (unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
REVENUES:        
Total revenues $ 303,717 $ 247,529 $ 555,147 $ 493,749
EXPENSES:        
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below) 53,124 45,053 94,144 92,264
Research and development 97,473 94,222 189,741 187,501
Selling, general and administrative 139,188 132,025 264,356 265,397
Amortization of acquired intangible assets 9,511 9,890 18,917 19,618
Total expenses 299,296 281,190 567,158 564,780
OPERATING INCOME (LOSS) 4,421 (33,661) (12,011) (71,031)
OTHER INCOME (EXPENSE), NET:        
Other (expense) income, net (222) 2,337 (615) 1,679
Interest income 623 1,788 1,487 4,548
Interest expense (2,407) (2,122) (6,377) (4,979)
Change in the fair value of contingent consideration 3,240 5,900 4,518 12,700
Total other income (expense), net 1,234 7,903 (987) 13,948
INCOME (LOSS) BEFORE INCOME TAXES 5,655 (25,758) (12,998) (57,083)
INCOME TAX PROVISION 3,291 3,673 7,056 11,002
NET INCOME (LOSS) $ 2,364 $ (29,431) $ (20,054) $ (68,085)
EARNINGS (LOSS) PER ORDINARY SHARE:        
Basic and diluted $ 0.01 $ (0.19) $ (0.13) $ (0.43)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:        
Basic 160,817 158,895 160,229 158,495
Diluted 163,937 158,895 160,229 158,495
COMPREHENSIVE INCOME (LOSS):        
Net income (loss) $ 2,364 $ (29,431) $ (20,054) $ (68,085)
Holding (loss) gain, net of a tax (benefit) provision of $(79), $409, $(253) and $496, respectively (272) 1,398 (873) 1,715
COMPREHENSIVE INCOME (LOSS) 2,092 (28,033) (20,927) (66,370)
Product sales, net        
REVENUES:        
Total revenues 160,808 130,415 290,771 260,141
Manufacturing and royalty revenues        
REVENUES:        
Total revenues 142,294 116,505 262,141 232,756
Research and development revenue        
REVENUES:        
Total revenues $ 615 $ 609 735 $ 852
License revenue        
REVENUES:        
Total revenues     $ 1,500