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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES: |  |
Net loss | $ (130,013) | $ (49,042)
Adjustments to reconcile net loss to cash flows from operating activities: |  |
Depreciation and amortization | 58,185 | 57,510
Share-based compensation expense | 67,771 | 68,603
Deferred income taxes | (54,073) | 2,015
Change in the fair value of contingent consideration | 21,750 | 677
Loss on debt extinguishment |  | 171
Other non-cash charges | 3,746 | 1,803
Changes in assets and liabilities: |  |
Receivables | 56,045 | (13,991)
Contract assets | 3,258 | 10,892
Inventory | (15,646) | (13,375)
Prepaid expenses and other assets | 1,872 | (1,507)
Right-of-use assets | 12,470 | 12,891
Accounts payable and accrued expenses | 4,810 | 15,546
Contract liabilities | (9,191) | (4,642)
Operating lease liabilities | (13,411) | (12,504)
Other long-term liabilities | 12,424 | (4,353)
Cash flows provided by operating activities | 19,997 | 70,694
CASH FLOWS FROM INVESTING ACTIVITIES: |  |
Additions of property, plant and equipment | (28,227) | (19,359)
Proceeds from the sale of equipment |  | 277
Proceeds from contingent consideration | 1,273 | 7,908
Return of Fountain Healthcare Partners II, L.P. investment | 485 |
Payment made for licensed Intellectual Property ("IP") |  | (1,000)
Purchases of investments | (256,806) | (294,370)
Sales and maturities of investments | 190,994 | 241,082
Cash flows used in investing activities | (92,281) | (65,462)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Proceeds from the issuance of ordinary shares under share-based compensation arrangements | 18,850 | 24,810
Employee taxes paid related to net share settlement of equity awards | (17,903) | (13,633)
Proceeds from the issuance of long-term debt |  | 23,567
Payment made for debt extinguishment |  | (993)
Principal payments of long-term debt | (2,250) | (1,500)
Cash flows (used in) provided by financing activities | (1,303) | 32,251
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS | (73,587) | 37,483
CASH AND CASH EQUIVALENTS—Beginning of period | 337,544 | 272,961
CASH AND CASH EQUIVALENTS—End of period | 263,957 | 310,444
Non-cash investing and financing activities: |  |
Purchased capital expenditures included in accounts payable and accrued expenses | $ 2,690 | $ 2,698

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