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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
REVENUES:        
Total revenues $ 252,357 $ 294,141 $ 807,121 $ 849,288
EXPENSES:        
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below) 50,625 49,561 164,144 143,705
Research and development 100,430 118,411 289,256 308,152
Selling, general and administrative 152,777 136,213 448,206 400,569
Amortization of acquired intangible assets 9,166 9,615 27,198 28,532
Total expenses 312,998 313,800 928,804 880,958
OPERATING LOSS (60,641) (19,659) (121,683) (31,670)
OTHER EXPENSE, NET:        
Interest income 2,239 468 3,708 1,955
Interest expense (3,552) (2,437) (8,271) (8,814)
Change in the fair value of contingent consideration (3,553) (5,195) (21,750) (677)
Other (expense) income, net (1,861) 288 2,380 (327)
Total other expense, net (6,727) (6,876) (23,933) (7,863)
LOSS BEFORE INCOME TAXES (67,368) (26,535) (145,616) (39,533)
INCOME TAX (BENEFIT) PROVISION (3,394) 2,453 (15,603) 9,509
NET LOSS $ (63,974) $ (28,988) $ (130,013) $ (49,042)
LOSS PER ORDINARY SHARE:        
Basic $ (0.39) $ (0.18) $ (0.79) $ (0.31)
Diluted $ (0.39) $ (0.18) $ (0.79) $ (0.31)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:        
Basic 164,282 161,456 163,541 160,642
Diluted 164,282 161,456 163,541 160,642
COMPREHENSIVE LOSS:        
Net loss $ (63,974) $ (28,988) $ (130,013) $ (49,042)
Holding loss, net of a tax benefit of $188, $72, $1,242 and $325, respectively (2,349) (249) (9,114) (1,122)
COMPREHENSIVE LOSS (66,323) (29,237) (139,127) (50,164)
Product sales, net        
REVENUES:        
Total revenues 199,380 157,737 561,435 448,508
Manufacturing and royalty revenues        
REVENUES:        
Total revenues 52,941 136,294 243,437 398,435
License revenue        
REVENUES:        
Total revenues     2,000 1,500
Research and development revenue        
REVENUES:        
Total revenues $ 36 $ 110 $ 249 $ 845