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Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share-based compensation Expense
Total share-based compensation expense	$ 26,051	$ 25,600	$ 67,771	$ 68,603
Cost of goods manufactured and sold
Share-based compensation Expense
Total share-based compensation expense	2,623	2,666	7,406	7,527
Research and development
Share-based compensation Expense
Total share-based compensation expense	6,858	7,960	19,688	19,154
Selling, general and administrative
Share-based compensation Expense
Total share-based compensation expense	$ 16,570	$ 14,974	$ 40,677	$ 41,922

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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- Definition

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+ References

No definition available.

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