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Loss Per Share - Schedule of Anti-Dilutive Outstanding Common Share Equivalent Excluded from Calculation of Net Loss Per Share (Details) - shares
shares in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Denominator:        
Anti-dilutive potential common share equivalent excluded from calculation of net loss per ordinary share 17,953 16,541 18,243 18,876
Stock Options        
Denominator:        
Anti-dilutive potential common share equivalent excluded from calculation of net loss per ordinary share 13,031 11,827 12,784 15,344
Restricted Stock Unit Awards        
Denominator:        
Anti-dilutive potential common share equivalent excluded from calculation of net loss per ordinary share 4,922 4,714 5,459 3,532