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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY (unaudited) - USD ($)
$ in Thousands
Total
Ordinary Shares
Additional Paid-In Capital
Accumulated Other Comprehensive Loss
Accumulated Deficit
Treasury Stock
BALANCE at Dec. 31, 2020 $ 1,066,982 $ 1,620 $ 2,685,647 $ (1,349) $ (1,492,849) $ (126,087)
BALANCE (in shares) at Dec. 31, 2020   162,269,220       (3,108,079)
Issuance of ordinary shares under employee stock plans 2,053 $ 18 2,035      
Issuance of ordinary shares under employee stock plans (in shares)   1,566,685        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (10,413)         $ (10,413)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (529,817)
Share-based compensation 15,552   15,552      
Unrealized loss on marketable securities, net of tax (benefit) provision (601)     (601)    
Net Income (Loss) (22,418)       (22,418)  
BALANCE at Mar. 31, 2021 1,051,155 $ 1,638 2,703,234 (1,950) (1,515,267) $ (136,500)
BALANCE (in shares) at Mar. 31, 2021   163,835,905       (3,637,896)
BALANCE at Dec. 31, 2020 1,066,982 $ 1,620 2,685,647 (1,349) (1,492,849) $ (126,087)
BALANCE (in shares) at Dec. 31, 2020   162,269,220       (3,108,079)
Unrealized loss on marketable securities, net of tax (benefit) provision (1,122)          
Net Income (Loss) (49,042)          
BALANCE at Sep. 30, 2021 1,096,168 $ 1,654 2,778,596 (2,471) (1,541,891) $ (139,720)
BALANCE (in shares) at Sep. 30, 2021   165,439,188       (3,752,965)
BALANCE at Mar. 31, 2021 1,051,155 $ 1,638 2,703,234 (1,950) (1,515,267) $ (136,500)
BALANCE (in shares) at Mar. 31, 2021   163,835,905       (3,637,896)
Issuance of ordinary shares under employee stock plans 18,445 $ 12 18,433      
Issuance of ordinary shares under employee stock plans (in shares)   1,129,869        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (707)         $ (707)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (31,752)
Share-based compensation 26,917   26,917      
Unrealized loss on marketable securities, net of tax (benefit) provision (272)     (272)    
Net Income (Loss) 2,364       2,364  
BALANCE at Jun. 30, 2021 1,097,902 $ 1,650 2,748,584 (2,222) (1,512,903) $ (137,207)
BALANCE (in shares) at Jun. 30, 2021   164,965,774       (3,669,648)
Issuance of ordinary shares under employee stock plans 4,312 $ 4 4,308      
Issuance of ordinary shares under employee stock plans (in shares)   473,414        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (2,513)         $ (2,513)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (83,317)
Share-based compensation 25,704   25,704      
Unrealized loss on marketable securities, net of tax (benefit) provision (249)     (249)    
Net Income (Loss) (28,988)       (28,988)  
BALANCE at Sep. 30, 2021 1,096,168 $ 1,654 2,778,596 (2,471) (1,541,891) $ (139,720)
BALANCE (in shares) at Sep. 30, 2021   165,439,188       (3,752,965)
BALANCE at Dec. 31, 2021 1,112,584 $ 1,658 2,798,325 (3,723) (1,541,018) $ (142,658)
BALANCE (in shares) at Dec. 31, 2021   165,790,549       (3,853,222)
Issuance of ordinary shares under employee stock plans 1,795 $ 19 1,776      
Issuance of ordinary shares under employee stock plans (in shares)   1,953,293        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (17,069)         $ (17,069)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (678,209)
Share-based compensation 18,494   18,494      
Unrealized loss on marketable securities, net of tax (benefit) provision (4,511)     (4,511)    
Net Income (Loss) (35,903)       (35,903)  
BALANCE at Mar. 31, 2022 1,075,390 $ 1,677 2,818,595 (8,234) (1,576,921) $ (159,727)
BALANCE (in shares) at Mar. 31, 2022   167,743,842       (4,531,431)
BALANCE at Dec. 31, 2021 1,112,584 $ 1,658 2,798,325 (3,723) (1,541,018) $ (142,658)
BALANCE (in shares) at Dec. 31, 2021   165,790,549       (3,853,222)
Unrealized loss on marketable securities, net of tax (benefit) provision (9,114)          
Net Income (Loss) (130,013)          
BALANCE at Sep. 30, 2022 1,042,854 $ 1,689 2,885,594 (12,837) (1,671,031) $ (160,561)
BALANCE (in shares) at Sep. 30, 2022   168,864,804       4,561,575
BALANCE at Mar. 31, 2022 1,075,390 $ 1,677 2,818,595 (8,234) (1,576,921) $ (159,727)
BALANCE (in shares) at Mar. 31, 2022   167,743,842       (4,531,431)
Issuance of ordinary shares under employee stock plans 16,197 $ 11 16,186      
Issuance of ordinary shares under employee stock plans (in shares)   1,038,859        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (514)         $ (514)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (18,566)
Share-based compensation 23,641   23,641      
Unrealized loss on marketable securities, net of tax (benefit) provision (2,254)     (2,254)    
Net Income (Loss) (30,136)       (30,136)  
BALANCE at Jun. 30, 2022 1,082,324 $ 1,688 2,858,422 (10,488) (1,607,057) $ (160,241)
BALANCE (in shares) at Jun. 30, 2022   168,782,701       (4,549,997)
Issuance of ordinary shares under employee stock plans 858 $ 1 857      
Issuance of ordinary shares under employee stock plans (in shares)   82,103        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (320)         $ (320)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (11,578)
Share-based compensation 26,315   26,315      
Unrealized loss on marketable securities, net of tax (benefit) provision (2,349)     (2,349)    
Net Income (Loss) (63,974)       (63,974)  
BALANCE at Sep. 30, 2022 $ 1,042,854 $ 1,689 $ 2,885,594 $ (12,837) $ (1,671,031) $ (160,561)
BALANCE (in shares) at Sep. 30, 2022   168,864,804       4,561,575