<SEC-DOCUMENT>0000899140-22-000583.txt : 20220706
<SEC-HEADER>0000899140-22-000583.hdr.sgml : 20220706
<ACCEPTANCE-DATETIME>20220706171541
ACCESSION NUMBER:		0000899140-22-000583
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20220706
DATE AS OF CHANGE:		20220706
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Alkermes plc.
		CENTRAL INDEX KEY:			0001520262
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				981007018
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-86627
		FILM NUMBER:		221069697

	BUSINESS ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		00-353-1-772-8000

	MAIL ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTLER SCIENCE TWO PLC
		DATE OF NAME CHANGE:	20110804

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Antler Science Two Ltd
		DATE OF NAME CHANGE:	20110509

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>s54639944a.htm
<DESCRIPTION>SCHEDULE 13D/A, AMENDMENT #5
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: asdf
         Document created using EDGARfilings PROfile 8.1.0.0
         Copyright 1995 - 2022 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div style="font-size: 12pt;"><br>
  </div>
  <div>
    <div style="text-align: center; margin-bottom: 12pt;"><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">UNITED STATES</font><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif;"><br>
      </font><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif;"><br>
      </font><font style="font-size: 12pt;">Washington, D.C. 20549</font></div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">SCHEDULE 13D</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center;"><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif;">(Amendment No. 5)*<br>
      </font><font style="font-size: 12pt;"><br>
      </font></div>
    <table cellspacing="0" cellpadding="0" id="z721eba8078e94556a4e49d42e3bb4914" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Alkermes Public Limited Company</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">(Name of Issuer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; font-size: 12pt;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Ordinary shares, $0.01 par value</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">(Title of Class of Securities)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; font-size: 12pt;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">G01767105</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">(CUSIP Number)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; font-size: 12pt;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">Mark DiPaolo</div>
            <div style="text-align: center; font-size: 12pt;">Senior Partner, General Counsel</div>
            <div style="text-align: center; font-size: 12pt;">Sarissa Capital Management LP</div>
            <div style="text-align: center; font-size: 12pt;">660 Steamboat Road</div>
            <div style="text-align: center; font-size: 12pt;">Greenwich, CT 06830</div>
            <div style="text-align: center; font-size: 12pt;">203-302-2330</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">(Name, Address and Telephone Number of Person<br>
              Authorized to Receive Notices and Communications)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; font-size: 12pt;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">July 6, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">(Date of Event which Requires Filing of this Statement)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify; margin-bottom: 12pt;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e),
      13d-1(f) or 13d-1(g), check the following box. &#9744;</div>
    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-weight: bold;">Note:</font>&#160; Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other
      parties to whom copies are to be sent.</div>
    <div>*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures
      provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that
      section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div><br>
    </div>
    <div>
      <div><br>
      </div>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zbe1b88486dfe49a1965950311f3e3865" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 50%; vertical-align: top; font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">CUSIP No. G01767105</div>
            </td>
            <td style="width: 50%; vertical-align: top; font-size: 12pt;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">Page 2 of&#160; 5&#160; Pages</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; margin-bottom: 18pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">SCHEDULE 13D</div>
    </div>
    <div> <br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="zcd16dde6f74d4c4f98d01711b97f62f9" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">1</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>NAME OF REPORTING PERSON OR<br>
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
              <br>
              Sarissa Capital Management LP</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">2</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div><br>
              (a) &#9744; &#160;&#160; </div>
            <div>(b) &#9744; &#160;&#160; </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">3</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">4</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SOURCE OF FUNDS<br>
              <br>
              WC</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">5</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">6</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION<br>
              <br>
              Delaware</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" rowspan="4" colspan="2">
            <div style="text-align: center;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">7</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE VOTING POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">8</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED VOTING POWER<br>
              <br>
              14,040,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">9</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE DISPOSITIVE POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">10</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED DISPOSITIVE POWER<br>
              <br>
              14,040,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>11</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>
              <br>
              14,040,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>12</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>&#160;&#9744;</div>
            <div> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>13</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>
              <br>
              8.55%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>14</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>TYPE OF REPORTING PERSON<br>
              &#160;</div>
            <div>PN</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 50%; vertical-align: top; font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">CUSIP No. G01767105</div>
            </td>
            <td style="width: 50%; vertical-align: top; font-size: 12pt;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">Page 3 of&#160; 5&#160; Pages</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; margin-bottom: 18pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">SCHEDULE 13D</div>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z63e86584674f483bbedda4c24dc0bea7" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">1</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>NAME OF REPORTING PERSON OR<br>
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
              <br>
              Alexander J. Denner, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">2</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div><br>
              (a)&#160;&#160; &#9744;&#160; <br>
            </div>
            <div>(b)&#160;&#160; &#9744; <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">3</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">4</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SOURCE OF FUNDS<br>
              <br>
              WC</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">5</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">6</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION<br>
              <br>
              United States</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" rowspan="4" colspan="2">
            <div style="text-align: center;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">7</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE VOTING POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">8</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED VOTING POWER<br>
              <br>
              14,040,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">9</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE DISPOSITIVE POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">10</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED DISPOSITIVE POWER<br>
              <br>
              14,040,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>11</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>
              <br>
              14,040,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>12</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>&#160;&#9744; <br>
            </div>
            <div> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>13</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>
              <br>
              8.55%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>14</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>TYPE OF REPORTING PERSON<br>
              &#160;</div>
            <div>IN</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 50%; vertical-align: top; font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">CUSIP No. G01767105</div>
            </td>
            <td style="width: 50%; vertical-align: top; font-size: 12pt;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">Page 4 of&#160; 5&#160; Pages</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; margin-bottom: 18pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">SCHEDULE 13D</div>
    </div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">This Amendment No. 5 to Schedule 13D (&#8220;Amendment No. 5&#8221;) relates to ordinary shares, par value $0.01 per share (&#8220;Common Stock&#8221; and, such shares, the &#8220;Shares&#8221;), issued by Alkermes
      Public Limited Company, a company incorporated under the laws of Ireland (the &#8220;Issuer&#8221;), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on May 10, 2021 (the &#8220;Initial Schedule 13D&#8221;), as
      amended by Amendment No. 1 to Schedule 13D filed on May 27, 2021 (&#8220;Amendment No. 1&#8221;), Amendment No. 2 to Schedule 13D filed on September 10, 2021 (&#8220;Amendment No. 2&#8221;), Amendment No. 3 to Schedule 13D filed on November 19, 2021 (&#8220;Amendment No. 3&#8221;) and
      Amendment No. 4 to Schedule 13D filed on January 10, 2022 (&#8220;Amendment No. 4&#8221; and together with the Initial Schedule 13D, Amendment No. 1, Amendment No. 2 and Amendment No. 3, the &#8220;Schedule 13D&#8221;), on behalf of the Reporting Persons, to furnish the
      additional information set forth herein. All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D.</div>
    <div style="margin-top: 6pt; margin-bottom: 6pt;"><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 4.&#160; Purpose of Transaction. </font><font style="font-size: 12pt;">Item 4 of the Schedule 13D is hereby
        amended to include the following:</font></div>
    <div style="margin-top: 6pt; margin-bottom: 6pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">On July 6, 2022,&#160;Sarissa Capital&#160;issued&#160;a press release&#160;indicating how the Reporting Persons intend to vote at the upcoming annual meeting of
      the Issuer and the reasons therefor. A copy of the press release is attached as Exhibit 3 hereto.</div>
    <div style="margin-top: 6pt; margin-bottom: 6pt;"><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 5.&#160; Interest in Securities of the Issuer. </font><font style="font-size: 12pt;">Item 5 (a) of the
        Schedule 13D is hereby amended and restated as follows:</font></div>
    <div style="margin-top: 6pt; margin-bottom: 6pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">(a) The Reporting Persons may be deemed to beneficially own, in the aggregate, 14,040,000 Shares representing approximately 8.55% of the
      outstanding Shares, based upon the 164,136,728 Shares outstanding as of June 1, 2022, as set forth in the definitive proxy statement of the Issuer filed with the U.S. Securities and Exchange Commission on June 6, 2022.</div>
    <div style="margin-top: 6pt; margin-bottom: 6pt;"><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 7. Material to Be Filed as Exhibits. </font><font style="font-size: 12pt;">Item 7 of the Schedule 13D
        is hereby amended to include the following:</font></div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Exhibit 3 &#8211; Press Release, July 6, 2022</div>
    <div style="margin-bottom: 12pt; font-size: 12pt;"><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 18pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 50%; vertical-align: top; font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">CUSIP No. G01767105</div>
            </td>
            <td style="width: 50%; vertical-align: top; font-size: 12pt;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">Page 5 of&#160; 5&#160; Pages</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; margin-bottom: 18pt; font-size: 12pt; font-weight: normal;">SCHEDULE 13D</div>
    </div>
    <div style="text-align: center; margin-bottom: 18pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">SIGNATURE</div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this
      statement is true, complete and correct.</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Dated:&#160; July 6, 2022</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">SARISSA CAPITAL MANAGEMENT LP</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif;">By:</font><font style="font-size: 12pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <font style="font-family: 'Times New Roman',Times,serif;"><u>/s/ Mark DiPaolo </u>_______________________<br>
          <font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; width: 36pt;">&#160;</font>Name: Mark DiPaolo<br>
          <font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; width: 36pt;">&#160;</font>Title: Senior Partner, General Counsel</font></font></div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif;"><u>/s/Alexander J. Denner</u></font><font style="font-size: 12pt;">________________________<font style="font-family: 'Times New Roman',Times,serif;"><br>
        </font>Alexander J. Denner</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-3
<SEQUENCE>2
<FILENAME>s54639944b.htm
<DESCRIPTION>PRESS RELEASE, JULY 6, 2022
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: asdf
         Document created using EDGARfilings PROfile 8.1.0.0
         Copyright 1995 - 2022 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div style="font-size: 12pt;">
    <div style="text-align: right; margin-bottom: 8pt; font-family: 'Times New Roman',Times,serif;">EXHIBIT 3</div>
  </div>
  <div style="font-size: 12pt;"><br>
  </div>
  <div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">SARISSA CAPITAL COMMENTS ON ALKERMES ANNUAL MEETING</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-style: italic;">Sarissa concerned that Alkermes Board is being unduly influenced by CEO Richard Pops</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-style: italic;">Sarissa supports new Alkermes directors to step up and act for the benefit of shareholders</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-style: italic;">Sarissa is considering taking action under Irish law to selectively remove and replace Alkermes directors</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Greenwich, CT, July 6, 2022 &#8211; Sarissa Capital Management LP (&#8220;Sarissa&#8221;) today made the following statement on Alkermes PLC (NASDAQ: ALKS) regarding how it intends to vote at the
      upcoming Alkermes annual meeting and the reasons therefor:</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Richard Pops, the CEO and Chairman of Alkermes, has presided over tremendous shareholder value destruction since becoming CEO of Alkermes over thirty years ago.&#160;&#160;Despite Alkermes
      growing revenues in the last five years and having annual revenues exceeding $1 billion, Alkermes has consistently operated at a net loss.&#160;&#160;During the same period, Alkermes stock has declined nearly 60% and underperformed the IBB by approximately
      130%.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Based on conversations with CEO Pops and its experience to date with the Alkermes nomination and governance process, Sarissa believes that certain of the independent directors
      are uncomfortable making decisions that are not supported by, or that reflect criticism of, CEO Pops.</div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">&#160;</div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Alex Denner and Richard Pops and others have had a number of conversations which we were hopeful would lead to a Sarissa representative working on the Alkermes board to create
      value for all shareholders.&#160; Unfortunately, Pops set forth a version of these conversations in the Alkermes&#8217; securities filings which is fraught with misleading statements, inaccuracies and material omissions.&#160;&#160;We believe Alkermes&#8217; alleged detailed
      summary of our communications is counterproductive, unprofessional, and more importantly, <font style="font-weight: bold;"><u>it is blatantly and materially</u><u>&#160;</u><u>incorrect</u></font>. In addition, we believe that a policy of releasing misleading summaries of our private conversations is low class. We caution others having seemingly private conversations with Richard Pops that
      he may be taking notes of each conversation that he intends to later release to the public in a self-serving and misleading way.&#160; &#160; &#160;&#160;</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Sarissa believes that its support of the recently appointed directors combined with the decisions of long tenured directors Anstice and Dixon, to not stand for re-election,
      should create an environment in the board room that will enable the directors to do the right thing for shareholders even in the face of resistance from Pops.&#160; &#160;</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">It is apparent to us that Richard Pops is trying very hard to keep a Sarissa person off the board of the company even though we own nearly $450 million in Alkermes stock.&#160;&#160;We
      believe he is worried that once in the boardroom we may decide that a new CEO&#160;would be better at creating value for shareholders than Richard Pops.&#160;&#160;As one of the largest shareholders, Sarissa has a vested interest in Alkermes&#8217; success. We have a
      long history of creating value for our companies. We believe Alkermes&#8217; shares are significantly undervalued and that we can help to unlock shareholder value with our representatives on the board. We are hopeful that the current board will agree with
      us.</div>
    <div style="font-size: 12pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Therefore, we intend to vote &#8220;for&#8221; the Alkermes slate of directors (which consists entirely of recently appointed directors) at the upcoming annual meeting.&#160;&#160;If, however, a
      Sarissa representative is not soon appointed to the Alkermes board, then we will take steps under Irish law to quickly call another shareholder meeting that seeks to selectively remove and replace certain board members with those that Sarissa
      believes will act in the best interest of shareholders.&#160;</div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">&#160;</div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Contact:&#160;</div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Jean Puong</div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">Sarissa Capital Management LP</div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">info@sarissacap.com</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <br>
    <br>
    <hr noshade="noshade" align="left" style="background-color: #000000; border: 0px; height: 1px; width: 2in; margin-left: 0pt; margin-right: auto; color: #000000;">
    <div><sup style="font-family: Calibri, sans-serif; vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup>&#160;Estimated by subtracting the percentage change of Alkermes&#8217; share price from the percentage change of IBB price from 12/30/16 to 12/30/21.</div>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
