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Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
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Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | $ 28,504 | $ 23,377 | $ 51,147 | $ 41,720
Cost of goods manufactured and sold |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | 2,921 | 2,401 | 5,603 | 4,783
Research and development |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | 7,506 | 7,222 | 14,413 | 12,830
Selling, general and administrative |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | $ 18,077 | $ 13,754 | $ 31,131 | $ 24,107

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org//1943274/2147479830/718-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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