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Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
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Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | $ 23,915 | $ 26,051 | $ 75,062 | $ 67,771
Cost of goods manufactured and sold |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | 2,939 | 2,623 | 8,542 | 7,406
Research and development |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | 7,208 | 6,858 | 21,621 | 19,688
Selling, general and administrative |  |  |  |
Share-based compensation Expense |  |  |  |
Total share-based compensation expense | $ 13,768 | $ 16,570 | $ 44,899 | $ 40,677

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org//1943274/2147479830/718-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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