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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) (unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
REVENUES:        
Total revenues $ 380,938 $ 252,357 $ 1,285,930 $ 807,121
EXPENSES:        
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below) 61,509 50,625 182,944 164,144
Research and development 97,140 100,430 291,565 289,256
Selling, general and administrative 169,446 152,777 549,181 448,206
Amortization of acquired intangible assets 8,995 9,166 26,693 27,198
Total expenses 337,090 312,998 1,050,383 928,804
OPERATING INCOME (LOSS) 43,848 (60,641) 235,547 (121,683)
OTHER INCOME (EXPENSE), NET:        
Interest income 9,370 2,239 21,105 3,708
Interest expense (6,006) (3,552) (16,978) (8,271)
Change in the fair value of contingent consideration   (3,553)   (21,750)
Other income (expense), net 149 (1,861) (415) 2,380
Total other income (expense), net 3,513 (6,727) 3,712 (23,933)
INCOME (LOSS) BEFORE INCOME TAXES 47,361 (67,368) 239,259 (145,616)
INCOME TAX BENEFIT (397) (3,394) (3,719) (15,603)
NET INCOME (LOSS) $ 47,758 $ (63,974) $ 242,978 $ (130,013)
EARNINGS (LOSS) PER ORDINARY SHARE:        
Basic $ 0.29 $ (0.39) $ 1.46 $ (0.79)
Diluted $ 0.28 $ (0.39) $ 1.42 $ (0.79)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:        
Basic 166,607 164,282 165,996 163,541
Diluted 171,903 164,282 170,981 163,541
COMPREHENSIVE INCOME (LOSS):        
Net income (loss) $ 47,758 $ (63,974) $ 242,978 $ (130,013)
Holding gain (loss), net of a tax provision (benefit) of $216, $(188), $803 and $(1,242), respectively 1,363 (2,349) 4,815 (9,114)
COMPREHENSIVE INCOME (LOSS) 49,121 (66,323) 247,793 (139,127)
Product sales, net        
REVENUES:        
Total revenues 231,822 199,380 678,026 561,435
Manufacturing and royalty revenues        
REVENUES:        
Total revenues 149,113 52,941 607,888 243,437
License revenue        
REVENUES:        
Total revenues       2,000
Research and development revenue        
REVENUES:        
Total revenues $ 3 $ 36 $ 16 $ 249