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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY (unaudited) - USD ($)
$ in Thousands
Total
Ordinary Shares
Additional Paid-In Capital
Accumulated Other Comprehensive Loss
Accumulated Deficit
Treasury Stock
BALANCE at Dec. 31, 2021 $ 1,112,584 $ 1,658 $ 2,798,325 $ (3,723) $ (1,541,018) $ (142,658)
BALANCE (in shares) at Dec. 31, 2021   165,790,549       (3,853,222)
Issuance of ordinary shares under employee stock plans 1,795 $ 19 1,776      
Issuance of ordinary shares under employee stock plans (in shares)   1,953,293        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (17,069)         $ (17,069)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (678,209)
Share-based compensation 18,494   18,494      
Unrealized gain (loss) on marketable securities, net of tax provision (4,511)     (4,511)    
Net income (loss) (35,903)       (35,903)  
BALANCE at Mar. 31, 2022 1,075,390 $ 1,677 2,818,595 (8,234) (1,576,921) $ (159,727)
BALANCE (in shares) at Mar. 31, 2022   167,743,842       (4,531,431)
BALANCE at Dec. 31, 2021 1,112,584 $ 1,658 2,798,325 (3,723) (1,541,018) $ (142,658)
BALANCE (in shares) at Dec. 31, 2021   165,790,549       (3,853,222)
Unrealized gain (loss) on marketable securities, net of tax provision (9,114)          
Net income (loss) (130,013)          
BALANCE at Sep. 30, 2022 1,042,854 $ 1,689 2,885,594 (12,837) (1,671,031) $ (160,561)
BALANCE (in shares) at Sep. 30, 2022   168,864,804       (4,561,575)
BALANCE at Mar. 31, 2022 1,075,390 $ 1,677 2,818,595 (8,234) (1,576,921) $ (159,727)
BALANCE (in shares) at Mar. 31, 2022   167,743,842       (4,531,431)
Issuance of ordinary shares under employee stock plans 16,197 $ 11 16,186      
Issuance of ordinary shares under employee stock plans (in shares)   1,038,859        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (514)         $ (514)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (18,566)
Share-based compensation 23,641   23,641      
Unrealized gain (loss) on marketable securities, net of tax provision (2,254)     (2,254)    
Net income (loss) (30,136)       (30,136)  
BALANCE at Jun. 30, 2022 1,082,324 $ 1,688 2,858,422 (10,488) (1,607,057) $ (160,241)
BALANCE (in shares) at Jun. 30, 2022   168,782,701       (4,549,997)
Issuance of ordinary shares under employee stock plans 858 $ 1 857      
Issuance of ordinary shares under employee stock plans (in shares)   82,103        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (320)         $ (320)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (11,578)
Share-based compensation 26,315   26,315      
Unrealized gain (loss) on marketable securities, net of tax provision (2,349)     (2,349)    
Net income (loss) (63,974)       (63,974)  
BALANCE at Sep. 30, 2022 1,042,854 $ 1,689 2,885,594 (12,837) (1,671,031) $ (160,561)
BALANCE (in shares) at Sep. 30, 2022   168,864,804       (4,561,575)
BALANCE at Dec. 31, 2022 1,043,753 $ 1,690 2,913,099 (10,889) (1,699,285) $ (160,862)
BALANCE (in shares) at Dec. 31, 2022   168,951,193       (4,574,184)
Issuance of ordinary shares under employee stock plans 2,874 $ 25 2,849      
Issuance of ordinary shares under employee stock plans (in shares)   2,567,603        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (24,744)         $ (24,744)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (885,652)
Share-based compensation 22,778   22,778      
Unrealized gain (loss) on marketable securities, net of tax provision 2,760     2,760    
Net income (loss) (41,845)       (41,845)  
BALANCE at Mar. 31, 2023 1,005,576 $ 1,715 2,938,726 (8,129) (1,741,130) $ (185,606)
BALANCE (in shares) at Mar. 31, 2023   171,518,796       (5,459,836)
BALANCE at Dec. 31, 2022 1,043,753 $ 1,690 2,913,099 (10,889) (1,699,285) $ (160,862)
BALANCE (in shares) at Dec. 31, 2022   168,951,193       (4,574,184)
Unrealized gain (loss) on marketable securities, net of tax provision 4,815          
Net income (loss) 242,978          
BALANCE at Sep. 30, 2023 1,355,583 $ 1,722 3,003,184 (6,074) (1,456,307) $ (186,942)
BALANCE (in shares) at Sep. 30, 2023   172,218,651       (5,504,556)
BALANCE at Mar. 31, 2023 1,005,576 $ 1,715 2,938,726 (8,129) (1,741,130) $ (185,606)
BALANCE (in shares) at Mar. 31, 2023   171,518,796       (5,459,836)
Issuance of ordinary shares under employee stock plans 9,126 $ 5 9,121      
Issuance of ordinary shares under employee stock plans (in shares)   457,105        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (540)         $ (540)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (17,777)
Share-based compensation 28,518   28,518      
Unrealized gain (loss) on marketable securities, net of tax provision 692     692    
Net income (loss) 237,065       237,065  
BALANCE at Jun. 30, 2023 1,280,437 $ 1,720 2,976,365 (7,437) (1,504,065) $ (186,146)
BALANCE (in shares) at Jun. 30, 2023   171,975,901       (5,477,613)
Issuance of ordinary shares under employee stock plans 3,113 $ 2 3,111      
Issuance of ordinary shares under employee stock plans (in shares)   242,750        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (796)         $ (796)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (26,943)
Share-based compensation 23,708   23,708      
Unrealized gain (loss) on marketable securities, net of tax provision 1,363     1,363    
Net income (loss) 47,758       47,758  
BALANCE at Sep. 30, 2023 $ 1,355,583 $ 1,722 $ 3,003,184 $ (6,074) $ (1,456,307) $ (186,942)
BALANCE (in shares) at Sep. 30, 2023   172,218,651       (5,504,556)