<SEC-DOCUMENT>0001140361-23-029760.txt : 20230614
<SEC-HEADER>0001140361-23-029760.hdr.sgml : 20230614
<ACCEPTANCE-DATETIME>20230614080008
ACCESSION NUMBER:		0001140361-23-029760
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230614
DATE AS OF CHANGE:		20230614

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Alkermes plc.
		CENTRAL INDEX KEY:			0001520262
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				981007018
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-86627
		FILM NUMBER:		231013018

	BUSINESS ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		00-353-1-772-8000

	MAIL ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTLER SCIENCE TWO PLC
		DATE OF NAME CHANGE:	20110804

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Antler Science Two Ltd
		DATE OF NAME CHANGE:	20110509

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>ny20009418x8_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
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    <div style="text-align: center; color: #000000;"><font style="font-size: 14pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">UNITED STATES</font><font style="font-size: 14pt; font-family: 'Times New Roman',Times,serif;"><br>
      </font><font style="font-size: 14pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font><br>
      <font style="font-size: 12pt;">Washington, D.C. 20549</font></div>
    <div>&#160;</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">SCHEDULE 13D</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000;">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center;"><font style="color: #000000;">(Amendment No. 10)*<br>
      </font><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 24pt;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Alkermes Public Limited Company</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">(Name of Issuer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">Ordinary shares, $0.01 par value</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">(Title of Class of Securities)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">G01767105</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">(CUSIP Number)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">Mark DiPaolo</div>
            <div style="text-align: center; color: #000000;">Senior Partner, General Counsel</div>
            <div style="text-align: center; color: #000000;">Sarissa Capital Management LP</div>
            <div style="text-align: center; color: #000000;">660 Steamboat Road</div>
            <div style="text-align: center; color: #000000;">Greenwich, CT 06830</div>
            <div style="text-align: center; color: #000000;">203-302-2330</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">(Name, Address and Telephone Number of Person<br>
              Authorized to Receive Notices and Communications)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">June 13, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">(Date of Event which Requires Filing of this Statement)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify; color: #000000;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f)
      or 13d-1(g), check the following box. &#9744;</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">Note:</font>&#160; Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
      to whom copies are to be sent.</div>
    <div>&#160;</div>
    <div style="color: #000000;">*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would
      alter disclosures provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify; color: #000000;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the
      liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div><br>
    </div>
    <div>
      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center">
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          <div style="text-align: center;">
            <table id="z3f2bcaa20085475283d2d05412b05d30" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

                <tr>
                  <td style="width: 50.00%;">CUSIP No. G01767105<br>
                  </td>
                  <td style="width: 50%; text-align: right;">Page 2 of 4 Pages<br>
                  </td>
                </tr>

            </table>
          </div>
          <div style="text-align: center;"> <br>
          </div>
          <div style="text-align: center;">SCHEDULE 13D</div>
        </div>
        <div style="color: #000000;"> <br>
        </div>
        <div style="color: #000000;">This Amendment No. 10 to Schedule 13D (&#8220;Amendment No. 10&#8221;) relates to ordinary shares, par value $0.01 per share (&#8220;Common Stock&#8221; and, such shares, the &#8220;Shares&#8221;), issued by Alkermes Public Limited Company, a company
          incorporated under the laws of Ireland (the &#8220;Issuer&#8221;), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on May 10, 2021 (the &#8220;Initial Schedule 13D&#8221;), as amended by Amendment No. 1 to
          Schedule 13D filed on May 27, 2021, Amendment No. 2 to Schedule 13D filed on September 10, 2021, Amendment No. 3 to Schedule 13D filed on November 19, 2021, Amendment No. 4 to Schedule 13D filed on January 10, 2022, Amendment No. 5 to Schedule
          13D filed on July 6, 2022, Amendment No. 6 to Schedule 13D filed on October 7, 2022, Amendment No. 7 to Schedule 13D filed on February 6, 2023, Amendment No. 8 to Schedule 13D filed on June 5, 2023, and Amendment No. 9 to Schedule 13D filed on
          June 12, 2023 (the Initial Schedule 13D, as so amended, the &#8220;Schedule 13D&#8221;), on behalf of the Reporting Persons, to furnish the additional information set forth herein. All capitalized terms contained herein but not otherwise defined shall have
          the meanings ascribed to such terms in the Schedule 13D.</div>
        <div><br>
        </div>
        <div><font style="font-weight: bold; color: #000000;">Item 4.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; color: #000000;">Purpose of Transaction.</font></div>
        <div><br>
        </div>
        <div>Item 4 of the Schedule 13D is hereby amended to include the following:</div>
        <div><br>
        </div>
        <div style="text-align: justify;">On June 13, 2023, Sarissa Capital issued the press release attached as Exhibit 6 hereto.</div>
        <div><br>
        </div>
        <div style="text-align: justify;"><font style="font-weight: bold; color: #000000;">Item 7.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold; color: #000000;">Material to Be Filed as Exhibits.</font></div>
        <div><br>
        </div>
        <div><font style="color: #000000;">Item 7 of the Schedule 13D </font>is hereby amended to include the following:</div>
        <div><br>
        </div>
        <div style="color: #000000;">Exhibit 6 - Press Release, June 13, 2023</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div style="page-break-after: always;" class="BRPFPageBreak">
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        <div style="text-align: center; color: #000000; font-weight: bold;">
          <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

              <tr>
                <td style="width: 50.00%;">CUSIP No. G01767105<br>
                </td>
                <td style="width: 50%; text-align: right;">Page 3 of 4 Pages<br>
                </td>
              </tr>

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        </div>
        <div style="text-align: center; color: #000000; font-weight: bold;"> <br>
        </div>
        <div style="text-align: center; color: #000000; font-weight: bold;"><font style="font-weight: normal;">SCHEDULE 13D</font> </div>
        <div style="text-align: center; color: #000000; font-weight: bold;"> <br>
        </div>
        <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURE</div>
        <div>&#160;</div>
        <div style="text-align: justify; text-indent: 36pt; color: #000000;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
        <div><br>
        </div>
        <div style="color: #000000;">Dated:&#160; June 14, 2023</div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z4f1a347fab23425b858087245f28a565" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td colspan="2" rowspan="1" style="width: 3%; vertical-align: top;">
                <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">SARISSA CAPITAL MANAGEMENT LP</div>
              </td>
              <td style="width: 2.52%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
              <td style="width: 2.52%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
              <td style="width: 2.52%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top; padding-bottom: 2px;">
                <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">By:</div>
              </td>
              <td style="width: 47%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">/s/ Mark DiPaolo <br>
                </div>
              </td>
              <td style="width: 2.52%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
              <td style="width: 47%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">
                <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">Name: Mark DiPaolo</div>
              </td>
              <td style="width: 2.52%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">
                <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">Title: Senior Partner, General Counsel</div>
              </td>
              <td style="width: 2.52%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
              <td style="width: 2.52%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
              <td style="width: 2.52%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td colspan="2" rowspan="1" style="width: 3%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">/s/Alexander J. Denner</div>
              </td>
              <td style="width: 2.52%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
              <td style="width: 47%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td colspan="2" rowspan="1" style="width: 3%; vertical-align: top;">
                <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">Alexander J. Denner</div>
              </td>
              <td style="width: 2.52%; vertical-align: top;">&#160;</td>
              <td style="width: 47%; vertical-align: top;">&#160;</td>
            </tr>

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                <tr>
                  <td style="width: 50.00%;">CUSIP No. G01767105<br>
                  </td>
                  <td style="width: 50%; text-align: right;">Page 4 of 4 Pages<br>
                  </td>
                </tr>

            </table>
            <div><font style="font-weight: normal;"> <br>
              </font></div>
            <div><font style="font-weight: normal;">SCHEDULE 13D</font></div>
            <br>
            INDEX TO EXHIBITS</div>
        </div>
        <div>
          <div><br>
          </div>
          <div style="color: #000000;"><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001520262/000119312521142486/d171777d8k.htm">Exhibit 1</a> - Form 8-K of the Issuer filed with the U.S. Securities and Exchange Commission on April 30, 2021
            (incorporated by reference in this Schedule 13D)*</div>
          <div><font style="color: #000000;"> </font><br>
          </div>
          <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000089914021000485/s42631058b.htm">Exhibit 2</a> - Joint Filing Agreement of the Reporting Persons, dated as of May 10, 2021*</div>
          <div><br>
          </div>
          <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000089914022000583/s54639944b.htm">Exhibit 3</a> - Press Release, July 6, 2022*</div>
          <div style="color: #000000;">&#160;</div>
          <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123028238/ny20009418x2_ex4.htm">Exhibit 4</a> - Press Release, June 5, 2023*</div>
          <div><br>
          </div>
          <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123029264/ny20009418x6_ex5.htm">Exhibit 5</a> - Press Release, June 9, 2023*</div>
          <div><br>
          </div>
          <div style="color: #000000;"><a href="ny20009418x8_ex6.htm">Exhibit 6</a> - Press Release, June 13, 2023</div>
          <div><br>
          </div>
          <div style="color: #000000;">&#160;* Previously filed.</div>
          <div style="color: #000000;"> <br>
          </div>
          <div style="color: #000000;">
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<DOCUMENT>
<TYPE>EX-99.6
<SEQUENCE>2
<FILENAME>ny20009418x8_ex6.htm
<DESCRIPTION>EXHIBIT 6
<TEXT>
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    <div style="text-align: center; font-size: 12pt; font-weight: bold;">
      <hr style="height: 4px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">
      <div style="text-align: right; font-size: 10pt;">EXHIBIT 6<br>
      </div>
    </div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;"> <font style="font-size: 10pt;"><br>
      </font></div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">SARISSA URGES SHAREHOLDERS TO VOTE FOR SARISSA NOMINEES TO </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">PROVIDE MUCH NEEDED OVERSIGHT AND ACCOUNTABILITY TO ALKERMES</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Sarissa does not understand why the Alkermes independent directors refuse to add Sarissa representatives to the board</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Sarissa believes the addition of its representatives to the Alkermes board can unlock shareholder value and allow Alkermes to achieve its true potential</div>
    <div><br>
    </div>
    <div style="text-align: justify; font-family: 'Times New Roman',Times,serif;">Greenwich, CT, June 13, 2023 &#8211; Sarissa Capital today released the following letter to shareholders of Alkermes plc (NASDAQ: ALKS):</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">June 13, 2023</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">Dear Fellow Alkermes Shareholders:</div>
    <div><br>
    </div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">We are one of Alkermes&#8217; largest, long-term shareholders, owning nearly $450 million of stock. We have a stellar track record of success unlocking shareholder value by working
      collaboratively in the boardroom. For the past few years, we have been attempting to gain representation on the Alkermes board. Despite Alkermes&#8217; ongoing process to refresh the board, a board with no shareholder representatives and incumbent
      directors with superfluous skill sets, the board has steadfastly refused to add our nominees.</div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">We have proposed excellent candidates and cannot understand why the Alkermes directors are prepared to spend such a tremendous amount of time and shareholder money to keep us
      out of the boardroom. We will clearly add a shareholder perspective that currently does not exist on the board.</div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">We believed our recent discussions with certain independent board members were positive and had hoped we could avoid a proxy contest and reach a settlement that would be
      beneficial for all shareholders. We offered reasonable settlement compromises including delaying our appointment to the board and making it contingent upon stock price targets not being met. <font style="font-weight: bold;"><u>Regrettably, however,
          the board shunned our compromises and indicated that they only would be willing to meet with us two times per year (with Chairman and CEO Pops present) if we drop our request for board representation (as you know, most companies meet with major
          shareholders at least four times per year as a matter of course).</u></font></div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">Nonetheless, we will continue our attempts to engage constructively with the independent directors in the hopes of avoiding a proxy contest and reaching an amicable settlement
      that will allow us to work together to unlock value for all shareholders. Unfortunately, after our multi-year experience engaging with Alkermes, we believe Chairman and CEO Pops has far too much control and not nearly enough oversight on the board to
      allow a shareholder-favorable settlement to occur. In fact, we learned that instead of focusing on running the company, Mr.&#160;Pops had recently undertaken a roadshow with investors (during the company&#8217;s quiet period and prior to the filing of any proxy
      materials with the SEC) that we understand involved Mr.&#160;Pops lobbying shareholders against Sarissa representation on the board.</div>
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    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">For over 30 years, Chairman and CEO Pops has presided over massive destruction of shareholder value at Alkermes, managing to operate a $1 billion revenue generating company
      (nearly 1/3 of which is cost-free royalty income) at a perpetual loss with limited oversight by the board and no accountability to shareholders. We do not believe this pattern of value destruction will change without a strong shareholder presence on
      the board. We believe Pops understands that shareholder representation on the board will likely result in greater accountability and oversight. That is why he has gone to great lengths to prevent it.</div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">Richard Pops and the board have undertaken a misleading smear campaign of our nominees and have now offered reasons for not including us on the board never previously offered
      by the company despite years of discussions with Pops and the board. Most recently, the board issued a presentation citing Alex Denner&#8217;s membership on the Biogen board as an irreconcilable conflict.&#160; Alkermes must know that no real conflict exists as
      the Alkermes board approved of another Biogen director to be added to the Alkermes board, specifically clearing such Biogen director of any potential conflict issues. <font style="font-weight: bold;"><u>Coincidentally, Alex Denner recently announced
          that he will not stand for re-election to the Biogen board at the upcoming annual meeting, eliminating any claim of conflict whatsoever.</u>&#160;</font></div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">In addition, Alkermes has cited Dr. Denner&#8217;s inclusion in an M&amp;A shareholder strike suit as a new basis to not include Dr. Denner on the Alkermes board. As you know,
      shareholder strike suits are a matter of course and occur in virtually every M&amp;A transaction. In fact, we can provide many instances where the current directors have been involved in shareholder lawsuits &#8211; some of which were outside of the
      typical M&amp;A context. For example, Alkermes lead independent director, Nancy Wysenski, was accused in a securities fraud and insider trading suit of overstating clinical trial results and then profiting by selling approximately $22 million of
      stock. After US Senator Charles Grassley wrote to the SEC to investigate the stock sale, Nancy Wysenski suddenly retired. The court in that action indicated that Nancy Wysenski may have retired due to her negligence in that matter.</div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">Richard Pops and the board have also been touting some short-term positive stock price performance at Alkermes as a reason to maintain the status quo. We are certainly pleased
      that the stock has recently performed better than it has in the past. Recall, in the last five years, Alkermes&#8217; stock price has declined nearly 40% and underperformed the iShares Biotechnology ETF (&#8220;<u>IBB</u>&#8221;) by approximately 54% (calculated by
      subtracting the percentage change of Alkermes&#8217; share price from the percentage change of IBB&#8217;s price from 06/12/2018 to 06/12/2023. Source: Bloomberg). However, we believe much of this positive short-term performance is the direct result of pressure
      from Sarissa and other shareholders to run the company for the benefit of shareholders. As you know, pressure from Elliott and Sarissa drove Alkermes to finally enact profitability targets after nearly 30 years of unchecked value destruction. We
      believe that once pressure from shareholders is removed, Pops will revert the company back to its old course of value destruction and will never address the fundamental issues at the company.</div>
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    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">Notably, in addition to issues with poor governance, expense management and capital allocation, Alkermes is basically a patchwork of subscale businesses. The revenue potential
      of the commercial products is restrained by subscale and expensive efforts. Selling, general and administrative expenses have run at an unreasonable percentage of commercial revenues for many years, and guidance continues to increase. The
      manufacturing business is undersized and, in addition to the mishaps and delays over the years, may very well be unprofitable. Research and development is inefficient and expensive with the company&#8217;s extended efforts in cancer not building on the
      company&#8217;s expertise in psychiatry. (Admitting the inefficiency of its endeavor into oncology, the company announced at the prodding of Sarissa and other investors its intention to spin the oncology business &#8211; a good first step but certainly too
      little, too late.) As a result, <font style="font-weight: bold;"><u>expenses are exorbitant as a percent of revenue (~113% for the year ended 2022) and outsized relative to Alkermes&#8217; peers even before accounting for the fact that roughly a third of
          revenue is typically derived from royalties that should fall directly to the bottom line.</u></font></div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">Despite the consistent under-performance and destruction of shareholder value, Mr.&#160;Pops has been handsomely rewarded for over thirty years. Alkermes went public in 1991. Since
      the Nasdaq Biotechnology Index&#8217;s creation in 1993, Alkermes has underperformed the NBI by nearly 1,600% (calculated by subtracting the total return of the NBI index from Alkermes&#8217; total return from 11/01/1993 to 06/12/2023. Source: Bloomberg). <font style="font-weight: bold;"><u>In the last 15 years alone, Alkermes has underperformed the NBI by 311% and Richard Pops has been rewarded with over $150 million in compensation.</u></font></div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">Our nominees are excellent. Each of Dr. Alex Denner, Dr. Sarah Schlesinger and Patrice Bonfiglio have the skills and the experience to unlock shareholder value at Alkermes.
      Moreover, they each understand that they work for the shareholders and will provide essential oversight of management and accountability to shareholders. Conversely, Richard Pops has been a constant part of Alkermes&#8217; underperformance since inception.
      He will never run Alkermes for the benefit of shareholders without strong shareholder representation on the board. Shane Cooke is a former long-time member of Alkermes&#8217; management team and direct report of Mr. Pops. We believe he is neither additive
      to the board nor ideal to be trusted to provide appropriate oversight of Mr. Pops given their long-standing relationship. Richard Gaynor is an oncologist who was added to the board by Mr. Pops because of his expertise in oncology at a time when the
      company was investing heavily in building an oncology franchise. Given the imminent spin of the company&#8217;s cancer assets, his expertise is no longer relevant.</div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">We are undertaking this proxy contest reluctantly. We own shares valued at nearly $450 million and have a long track record of success generating value for shareholders of
      healthcare companies by working collaboratively in the boardroom. We have been attempting to engage constructively with the independent directors for several years. Our candidates are excellent and fill obvious needs on the board (certain incumbent
      Alkermes directors are redundant and/or superfluous). <font style="font-weight: bold;"><u>We cannot understand why the board is prepared to spend such a tremendous amount of time and shareholder funds to keep us out of the boardroom.</u></font></div>
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    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">The Alkermes directors have not articulated to us any substantive considerations not to endorse our nominees. We have offered reasonable compromises to settle this proxy
      contest but unfortunately the board has rejected us at every turn. Nonetheless, we remain undeterred. We firmly believe shareholder representation on the board is critical to unlocking Alkermes&#8217; true potential. And we will continue to attempt to
      engage constructively with the board so that our representatives have a seat in the boardroom and can truly advocate for oversight and accountability.</div>
    <div>&#160;</div>
    <div style="text-indent: 20pt; font-family: 'Times New Roman',Times,serif;">We urge our fellow Alkermes shareholders to vote the BLUE universal proxy card &#8220;FOR&#8221; all Sarissa Nominees to provide much needed oversight and accountability at Alkermes. We
      look forward to continuing our engagement with our fellow shareholders in the coming weeks. Thank you for your continued support.</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">Sarissa Capital Management LP</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">For additional information please visit our website at upgradealkermes.com.</div>
    <div style="font-family: 'Times New Roman',Times,serif;">#UpgradeAlkermes</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">If you have any questions regarding your BLUE universal proxy card or need assistance in executing your proxy card, please contact:</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">D.F.&#160; King &amp; Co., Inc.</div>
    <div style="font-family: 'Times New Roman',Times,serif;">Shareholders call Toll-Free: (866) 207-3648</div>
    <div style="font-family: 'Times New Roman',Times,serif;">All Others Call: (212) 493-6952</div>
    <div style="font-family: 'Times New Roman',Times,serif;">Email: ALKS@dfking.com</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">Your vote at Alkermes&#8217; Annual General Meeting of Shareholders on June 29, 2023 is very important.&#160; <font style="font-weight: bold;">We urge all shareholders to vote &#8220;<u>FOR</u>&#8221; the election of
        the Sarissa Nominees, &#8220;<u>AGAINST</u>&#8221;&#160;the compensation of the Company&#8217;s named executive officers,&#160;and &#8220;<u>FOR</u>&#8221; all other proposals in our proxy statement.</font></div>
    <div>&#160;</div>
    <div style="font-family: 'Times New Roman',Times,serif;">You can vote in one of three easy ways: by internet at www.cesvote.com, by telephone at 1-888-693-8683 or by mail using the <font style="font-weight: bold;"><u>BLUE</u></font> universal proxy
      card and postage-paid envelope sent to you.</div>
    <div>&#160;</div>
    <div style="font-family: 'Times New Roman',Times,serif;">If you vote by internet or telephone, you will be required to provide the unique control number printed&#160;on your <font style="font-weight: bold;"><u>BLUE</u></font> universal proxy card.</div>
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        <tr>
          <td style="width: 72pt; vertical-align: top; font-family: 'Times New Roman',Times,serif;">Contact:</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman',Times,serif;">Dayna Packes<br>
              Sarissa Capital Management LP<br>
              info@sarissacap.com</div>
          </td>
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    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Additional Information</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">Sarissa Capital Management LP (&#8220;Sarissa Capital&#8221;), together with other participants, filed a definitive proxy statement and an accompanying BLUE universal proxy card with the SEC on June 2, 2023,
      in connection with the solicitation of shareholders of the Company for the 2023 annual general meeting of shareholders (the &#8220;Annual Meeting&#8221;).&#160; Shareholders are advised to read the definitive proxy statement and other documents related to the Annual
      Meeting as they contain important information.</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">The definitive proxy statement and other relevant documents are available at no charge on the SEC&#8217;s website at www.sec.gov.&#160; The definitive proxy statement and other relevant documents filed by
      Sarissa Capital are also available at no charge at www.upgradealkermes.com or by directing a request to Sarissa Capital&#8217;s proxy solicitor, D.F.&#160; King &amp; Co., Inc., 48 Wall Street, New York, New York 10005 (Shareholders can call toll-free: (866)
      207-3648).</div>
    <div style="font-family: 'Times New Roman',Times,serif;"> <br>
    </div>
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