<SEC-DOCUMENT>0001140361-23-030633.txt : 20230621
<SEC-HEADER>0001140361-23-030633.hdr.sgml : 20230621
<ACCEPTANCE-DATETIME>20230621080018
ACCESSION NUMBER:		0001140361-23-030633
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230621
DATE AS OF CHANGE:		20230621

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Alkermes plc.
		CENTRAL INDEX KEY:			0001520262
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				981007018
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-86627
		FILM NUMBER:		231027425

	BUSINESS ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		00-353-1-772-8000

	MAIL ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTLER SCIENCE TWO PLC
		DATE OF NAME CHANGE:	20110804

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Antler Science Two Ltd
		DATE OF NAME CHANGE:	20110509

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>brhc20054642_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
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    <div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt;">Washington, D.C. 20549</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">SCHEDULE 13D</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000;">Under the Securities Exchange Act of 1934</div>
      <div style="text-align: center; color: #000000;">(Amendment No. 12)*</div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z82a8357fa7f94c4bb5403ed07c134143">

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            <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 24pt;">
              <div style="text-align: center; color: rgb(0, 0, 0);">Alkermes Public Limited Company</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="text-align: center; color: #000000;">(Name of Issuer)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="text-align: center; color: #000000;">Ordinary shares, $0.01 par value</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="text-align: center; color: #000000;">(Title of Class of Securities)</div>
            </td>
          </tr>

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      <div><br>
      </div>
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            <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="text-align: center; color: #000000;">G01767105</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="text-align: center; color: #000000;">(CUSIP Number)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="text-align: center; color: #000000;"> <br>
              </div>
              <div style="text-align: center; color: #000000;">Mark DiPaolo</div>
              <div style="text-align: center; color: #000000;">Senior Partner, General Counsel</div>
              <div style="text-align: center; color: #000000;">Sarissa Capital Management LP</div>
              <div style="text-align: center; color: #000000;">660 Steamboat Road</div>
              <div style="text-align: center; color: #000000;">Greenwich, CT 06830</div>
              <div style="text-align: center; color: #000000;">203-302-2330</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="text-align: center; color: #000000;">(Name, Address and Telephone Number of Person</div>
              <div style="text-align: center; color: #000000;">Authorized to Receive Notices and Communications)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="text-align: center; color: #000000;">June 20, 2023</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="text-align: center; color: #000000;">(Date of Event which Requires Filing of this Statement)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e),
        13d-1(f) or 13d-1(g), check the following box. &#9744;</div>
      <div>&#160;</div>
      <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">Note:</font>&#160; Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
        to whom copies are to be sent.</div>
      <div>&#160;</div>
      <div style="color: #000000;">*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which
        would alter disclosures provided in a prior cover page.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the
        liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
      <div><br>
      </div>
      <div>
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
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                <td style="width: 46.6%; vertical-align: top;">
                  <div>CUSIP No. G01767105</div>
                </td>
                <td style="width: 53.4%; vertical-align: top;">
                  <div style="text-align: right;">Page <font class="BRPFPageNumber">2</font> of 4 Pages</div>
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                <td colspan="2" rowspan="1" style="width: 46.6%; vertical-align: top;">
                  <div style="text-align: center;">SCHEDULE 13D</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <div style="color: #000000;"> </div>
      <div style="color: #000000;">This Amendment No. 12 to Schedule 13D (&#8220;Amendment No. 12&#8221;) relates to ordinary shares, par value $0.01 per share (&#8220;Common Stock&#8221; and, such shares, the &#8220;Shares&#8221;), issued by Alkermes Public Limited Company, a company
        incorporated under the laws of Ireland (the &#8220;Issuer&#8221;), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on May 10, 2021 (the &#8220;Initial Schedule 13D&#8221;), as amended by Amendment No. 1 to
        Schedule 13D filed on May 27, 2021, Amendment No. 2 to Schedule 13D filed on September 10, 2021, Amendment No. 3 to Schedule 13D filed on November 19, 2021, Amendment No. 4 to Schedule 13D filed on January 10, 2022, Amendment No. 5 to Schedule 13D
        filed on July 6, 2022, Amendment No. 6 to Schedule 13D filed on October 7, 2022, Amendment No. 7 to Schedule 13D filed on February 6, 2023, Amendment No. 8 to Schedule 13D filed on June 5, 2023, Amendment No. 9 to Schedule 13D filed on June 12,
        2023, Amendment No. 10 to Schedule 13D filed on June 14, 2023 and Amendment No. 11 to Schedule 13D filed on June 16, 2023 (the Initial Schedule 13D, as so amended, the &#8220;Schedule 13D&#8221;), on behalf of the Reporting Persons, to furnish the additional
        information set forth herein. All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D.</div>
      <div><br>
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="zc975f3aec8fe4ef1bcee734b389b2133" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;">

            <tr style="vertical-align: top;">
              <td style="text-align: right; vertical-align: top; width: 36pt;">
                <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 4.</font></div>
              </td>
              <td style="text-align: left; vertical-align: top; width: auto;">
                <div><font style="font-weight: bold; color: #000000;">Purpose of Transaction.</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div>Item 4 of the Schedule 13D is hereby amended to include the following:</div>
      <div><br>
      </div>
      <div style="text-align: justify;">On June 20, 2023, Sarissa Capital issued the press release attached as Exhibit 8 hereto.</div>
      <div><br>
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z0049d66470d34ddf9e124b556d558263" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;">

            <tr style="vertical-align: top;">
              <td style="text-align: right; vertical-align: top; width: 36pt;">
                <div style="text-align: justify;"><font style="font-weight: bold; color: rgb(0, 0, 0);">Item 7.</font> <br>
                </div>
              </td>
              <td style="text-align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold; color: #000000;">Material to Be Filed as Exhibits.</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div><font style="color: #000000;">Item 7 of the Schedule 13D </font>is hereby amended to include the following:</div>
      <div><br>
      </div>
      <div style="color: #000000;">Exhibit 8 - Press Release, June 20, 2023</div>
      <div style="color: #000000;"> <br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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              <tr>
                <td style="width: 46.6%; vertical-align: top;">
                  <div>CUSIP No. G01767105</div>
                </td>
                <td style="width: 53.4%; vertical-align: top;">
                  <div style="text-align: right;">Page <font class="BRPFPageNumber">3</font> of 4 Pages</div>
                </td>
              </tr>
              <tr>
                <td colspan="2" rowspan="1" style="width: 46.6%; vertical-align: top;">
                  <div style="text-align: center;">SCHEDULE 13D</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURE</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: #000000;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="ze32aa24b86204f9c9f214048da238b0a">

          <tr>
            <td colspan="3" rowspan="1" style="vertical-align: top;">
              <div style="color: #000000;">Dated:&#160; June 21, 2023</div>
            </td>
          </tr>
          <tr>
            <td colspan="3" rowspan="1" style="vertical-align: top;">&#160;&#160;</td>
          </tr>
          <tr>
            <td colspan="3" rowspan="1" style="vertical-align: top;">
              <div style="color: #000000;">SARISSA CAPITAL MANAGEMENT LP</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; padding-bottom: 2px;">
              <div style="color: #000000;">By:</div>
            </td>
            <td style="width: 42%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000;">/s/ Mark DiPaolo</div>
            </td>
            <td style="width: 55%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: #000000;">Name: Mark DiPaolo</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: #000000;">Title: Senior Partner, General Counsel</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zef13330955d7465caf32c853ad9ebfed">

          <tr>
            <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000;">/s/Alexander J. Denner</div>
            </td>
            <td style="width: 55%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: #000000;">Alexander J. Denner</div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
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              <tr>
                <td style="width: 46.6%; vertical-align: top;">
                  <div>CUSIP No. G01767105</div>
                </td>
                <td style="width: 53.4%; vertical-align: top;">
                  <div style="text-align: right;">Page <font class="BRPFPageNumber">4</font> of 4 Pages</div>
                </td>
              </tr>
              <tr>
                <td colspan="2" rowspan="1" style="width: 46.6%; vertical-align: top;">
                  <div style="text-align: center;">SCHEDULE 13D</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <div>
        <div style="text-align: center; color: #000000; font-weight: bold;">INDEX TO EXHIBITS</div>
      </div>
      <div>
        <div><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001520262/000119312521142486/d171777d8k.htm">Exhibit 1</a> - Form 8-K of the Issuer filed with the U.S. Securities and Exchange Commission on April 30, 2021
          (incorporated by reference in this Schedule 13D)*</div>
        <div><font style="color: #000000;"> </font><br>
        </div>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z0c66ceb61a624a10a4f8cb623aa06a65">

          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000089914021000485/s42631058b.htm">Exhibit 2</a> - Joint Filing Agreement of the Reporting Persons, dated as of May 10, 2021*</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000089914022000583/s54639944b.htm">Exhibit 3</a> - Press Release, July 6, 2022*</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123028238/ny20009418x2_ex4.htm">Exhibit 4</a> - Press Release, June 5, 2023*</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123029264/ny20009418x6_ex5.htm">Exhibit 5</a> - Press Release, June 9, 2023*</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123029760/ny20009418x8_ex6.htm">Exhibit 6</a> - Press Release, June 13, 2023*</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1577524/000114036123030189/ny20009418x10_ex7.htm">Exhibit 7</a> - Press Release, June 15, 2023*</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="color: #000000;"><a href="brhc20054642_ex8.htm">Exhibit 8</a> - Press Release, June 20, 2023</div>
            </td>
          </tr>

      </table>
      <div>
        <div><br>
        </div>
        <div style="color: #000000;">&#160;* Previously filed.</div>
        <div><br>
        </div>
      </div>
      <br>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.8
<SEQUENCE>2
<FILENAME>brhc20054642_ex8.htm
<DESCRIPTION>EXHIBIT 8
<TEXT>
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      <div style="text-align: right; font-weight: bold;">EXHIBIT 8<br>
      </div>
      <div style="color: rgb(0, 0, 0);"> <br>
        <div style="text-align: center; font-weight: bold;">INDEPENDENT PROXY ADVISORY FIRM ISS CONCLUDES THAT SARISSA CAPITAL HAS MADE A COMPELLING CASE FOR CHANGE TO THE ALKERMES BOARD</div>
        <div><br>
        </div>
        <div style="text-align: center; font-weight: bold;">ISS recommends that Alkermes shareholders vote the Blue Card &#8220;FOR&#8221; the election of Sarissa nominee Dr. Sarah Schlesinger to the Alkermes board</div>
        <div><br>
        </div>
        <div style="text-align: center; font-weight: bold;">ISS recommends that Alkermes shareholders vote &#8220;AGAINST&#8221; incumbent Alkermes director Richard Gaynor</div>
        <div><br>
        </div>
        <div style="text-align: justify;">Greenwich, CT, June 20, 2023 &#8211; Sarissa Capital Management LP (&#8220;Sarissa&#8221;) today made the following announcement regarding the conclusion reached by independent proxy advisory firm ISS that Sarissa has made a
          compelling case for change to the board of directors of Alkermes plc (NASDAQ: ALKS):</div>
        <div><br>
        </div>
        <div>We are pleased that ISS recognizes the compelling case for change to the Alkermes board. In particular, ISS noted that &#8220;the failure to deliver profitability is a sign that [Alkermes] has not done enough to regain shareholders&#8217; trust&#8221; and that
          &#8220;[Sarissa Capital] has made a compelling case that the prolonged inability of the incumbent leadership to transition to profitability warrants change in the boardroom.&#8221; Therefore, ISS concludes that shareholders&#8217; interests would be best served by
          adding a direct shareholder representative to the Alkermes board.</div>
        <div><br>
        </div>
        <div>ISS also concludes that with the pending spin of its cancer business, the value of Alkermes&#8217; incumbent director Richard Gaynor will be reduced and therefore he should be removed from the Alkermes board.</div>
        <div><br>
        </div>
        <div>Fellow Alkermes shareholders face an important decision at our upcoming annual shareholder meeting. Like ISS, we believe it is important to add direct shareholder representation to the Alkermes board. In our view, shareholder representation is
          critical to unlock the true potential of Alkermes and to provide the necessary oversight and accountability to prevent a reversion to the status quo of the last 30 years of underperformance under the leadership of Chairman and CEO Richard Pops.</div>
        <div><br>
        </div>
        <div>Your vote at Alkermes' Annual General Meeting of Shareholders on June 29, 2023 is very important. <font style="font-weight: bold;">We urge all shareholders to vote "<u>FOR</u>" the election of the Sarissa Nominees, &#8220;<u>AGAINST</u>&#8221; the
            compensation of the Company&#8217;s named executive officers, and "<u>FOR</u>" all other proposals in our proxy statement.</font></div>
        <div><br>
        </div>
        <div>For additional information please visit our website at upgradealkermes.com.</div>
        <div>#UpgradeAlkermes</div>
        <div><br>
        </div>
        <div>If you have any questions regarding your BLUE universal proxy card or need assistance in executing your proxy card, please contact:</div>
        <div> <br>
        </div>
        <div>
          <div style="font-weight: bold;">D.F.&#160; King &amp; Co., Inc.</div>
          <div>Shareholders call Toll-Free: (866) 207-3648</div>
          <div>All Others Call: (212) 493-6952</div>
          <div>Email: <u>ALKS@dfking.com</u></div>
        </div>
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        <div>You can vote in one of three easy ways: by internet at <u>www.cesvote.com</u>, by telephone at 1-888-693-8683 or by mail using the <font style="font-weight: bold;"><u>BLUE</u></font> universal proxy card and postage-paid envelope sent to
          you.</div>
        <div>&#160;</div>
        <div>If you vote by internet or telephone, you will be required to provide the unique control number printed on your <font style="font-weight: bold;"><u>BLUE</u></font> universal proxy card.</div>
        <div>&#160;</div>
        <table cellspacing="0" cellpadding="0" border="0" id="zfaf3308c5cf94800bcad54d9a83b943f" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

            <tr>
              <td style="width: 10%; vertical-align: top;">
                <div>Contact:</div>
              </td>
              <td style="width: 90%; vertical-align: top;">
                <div>Dayna Packes</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top;">&#160;</td>
              <td style="width: 90%; vertical-align: top;">
                <div>Sarissa Capital Management LP</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top;">&#160;</td>
              <td style="width: 90%; vertical-align: top;">
                <div><u>info@sarissacap.com</u></div>
              </td>
            </tr>

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        <div style="font-weight: bold;">Additional Information</div>
        <div><br>
        </div>
        <div>Sarissa Capital Management LP (&#8220;Sarissa Capital&#8221;), together with other participants, filed a definitive proxy statement and an accompanying BLUE universal proxy card with the SEC on June 2, 2023, in connection with the solicitation of
          shareholders of the Company for the 2023 annual general meeting of shareholders (the &#8220;Annual Meeting&#8221;).&#160; Shareholders are advised to read the definitive proxy statement and other documents related to the Annual Meeting as they contain important
          information.</div>
        <div><br>
        </div>
        <div>The definitive proxy statement and other relevant documents are available at no charge on the SEC&#8217;s website at www.sec.gov.&#160; The definitive proxy statement and other relevant documents filed by Sarissa Capital are also available at no charge
          at www.upgradealkermes.com or by directing a request to Sarissa Capital&#8217;s proxy solicitor, D.F.&#160; King &amp; Co., Inc., 48 Wall Street, New York, New York 10005 (Shareholders can call toll-free: (866) 207-3648).</div>
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