<SEC-DOCUMENT>0001140361-23-031057.txt : 20230623
<SEC-HEADER>0001140361-23-031057.hdr.sgml : 20230623
<ACCEPTANCE-DATETIME>20230623080020
ACCESSION NUMBER:		0001140361-23-031057
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230623
DATE AS OF CHANGE:		20230623
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Alkermes plc.
		CENTRAL INDEX KEY:			0001520262
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				981007018
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-86627
		FILM NUMBER:		231034887

	BUSINESS ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		00-353-1-772-8000

	MAIL ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTLER SCIENCE TWO PLC
		DATE OF NAME CHANGE:	20110804

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Antler Science Two Ltd
		DATE OF NAME CHANGE:	20110509

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>brhc20054765_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
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    <div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt;">Washington, D.C. 20549</div>
      <div style="text-align: center; color: #000000; font-weight: bold;"><font style="font-size: 12pt;"> </font><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">SCHEDULE 13D</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000;">Under the Securities Exchange Act of 1934</div>
      <div style="text-align: center; color: #000000;">(Amendment No. 13)*</div>
      <div style="color: rgb(0, 0, 0);"> <br>
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" border="0" id="z79892d567ff4492dada51f7d71e025ce" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 100%; vertical-align: top; font-size: 24pt; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">Alkermes Public Limited Company</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">
                <div style="text-align: center; color: #000000;">(Name of Issuer)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">Ordinary shares, $0.01 par value</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">
                <div style="text-align: center; color: #000000;">(Title of Class of Securities)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">G01767105</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">
                <div style="text-align: center; color: #000000;">(CUSIP Number)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">Mark DiPaolo</div>
                <div style="text-align: center; color: #000000;">Senior Partner, General Counsel</div>
                <div style="text-align: center; color: #000000;">Sarissa Capital Management LP</div>
                <div style="text-align: center; color: #000000;">660 Steamboat Road</div>
                <div style="text-align: center; color: #000000;">Greenwich, CT 06830</div>
                <div style="text-align: center; color: #000000;">203-302-2330</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">
                <div style="text-align: center; color: #000000;">(Name, Address and Telephone Number of Person<br>
                  Authorized to Receive Notices and Communications)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">June 22, 2023</div>
              </td>
            </tr>
            <tr>
              <td style="width: 100%; vertical-align: top;">
                <div style="text-align: center; color: #000000;">(Date of Event which Requires Filing of this Statement)</div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e),
        13d-1(f) or 13d-1(g), check the following box. &#9744;</div>
      <div>&#160;</div>
      <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">Note:</font>&#160; Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
        to whom copies are to be sent.</div>
      <div>&#160;</div>
      <div style="color: #000000;">*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which
        would alter disclosures provided in a prior cover page.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the
        liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
      <div style="text-align: justify; color: #000000;"> <br>
      </div>
      <div style="text-align: justify; color: #000000;">
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
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            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 46.6%; vertical-align: top;">
                    <div style="font-size: 8pt;">CUSIP No. G01767105</div>
                  </td>
                  <td style="width: 53.4%; vertical-align: top;">
                    <div style="text-align: right; font-size: 8pt;">Page <font class="BRPFPageNumber">2</font> of 4 Pages</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: center; font-size: 8pt;">SCHEDULE 13D</div>
          </div>
        </div>
      </div>
      <div style="color: #000000;">This Amendment No. 13 to Schedule 13D (&#8220;Amendment No. 13&#8221;) relates to ordinary shares, par value $0.01 per share (&#8220;Common Stock&#8221; and, such shares, the &#8220;Shares&#8221;), issued by Alkermes Public Limited Company, a company
        incorporated under the laws of Ireland (the &#8220;Issuer&#8221;), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on May 10, 2021 (the &#8220;Initial Schedule 13D&#8221;), as amended by Amendment No. 1 to
        Schedule 13D filed on May 27, 2021, Amendment No. 2 to Schedule 13D filed on September 10, 2021, Amendment No. 3 to Schedule 13D filed on November 19, 2021, Amendment No. 4 to Schedule 13D filed on January 10, 2022, Amendment No. 5 to Schedule 13D
        filed on July 6, 2022, Amendment No. 6 to Schedule 13D filed on October 7, 2022, Amendment No. 7 to Schedule 13D filed on February 6, 2023, Amendment No. 8 to Schedule 13D filed on June 5, 2023, Amendment No. 9 to Schedule 13D filed on June 12,
        2023, Amendment No. 10 to Schedule 13D filed on June 14, 2023, Amendment No. 11 to Schedule 13D filed on June 16, 2023 and Amendment No. 12 to Schedule 13D filed on June 21, 2023 (the Initial Schedule 13D, as so amended, the &#8220;Schedule 13D&#8221;), on
        behalf of the Reporting Persons, to furnish the additional information set forth herein. All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D.</div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2b6d592b4dda445eb54bbf9342335da7">

          <tr>
            <td style="width: 45pt; vertical-align: top; color: #000000; font-weight: bold;">Item 4.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;"> Purpose of Transaction.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div>Item 4 of the Schedule 13D is hereby amended to include the following:</div>
      <div><br>
      </div>
      <div style="text-align: justify;">On June 22, 2023, Sarissa Capital issued the press release attached as Exhibit 9 hereto.</div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z8ceed4f580ec42c4b92d2bae05200780">

          <tr>
            <td style="width: 45pt; vertical-align: top; color: #000000; font-weight: bold;">Item 7.</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="color: #000000; font-weight: bold;"> Material to Be Filed as Exhibits.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div><font style="color: #000000;">Item 7 of the Schedule 13D </font>is hereby amended to include the following:</div>
      <div><br>
      </div>
      <div style="color: #000000;">Exhibit 9 - Press Release, June 22, 2023</div>
      <div><br>
      </div>
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                <tr>
                  <td style="width: 46.6%; vertical-align: top;">
                    <div style="font-size: 8pt;">CUSIP No. G01767105</div>
                  </td>
                  <td style="width: 53.4%; vertical-align: top;">
                    <div style="text-align: right; font-size: 8pt;">Page <font class="BRPFPageNumber">3</font> of 4 Pages</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: center; font-size: 8pt;">SCHEDULE 13D</div>
          </div>
        </div>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURE</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; color: #000000;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zdf41e7d05e1048829a852c7af72a68fd">

          <tr>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: #000000;">Dated:&#160; June 23, 2023</div>
            </td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: #000000;">SARISSA CAPITAL MANAGEMENT LP</div>
            </td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top; padding-bottom: 2px;">
              <div style="color: #000000;">By:</div>
            </td>
            <td style="width: 47%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000;">/s/ Mark DiPaolo</div>
            </td>
            <td style="width: 49.8%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 47%; vertical-align: top;">
              <div style="color: #000000;">Name: Mark DiPaolo</div>
            </td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 47%; vertical-align: top;">
              <div style="color: #000000;">Title: Senior Partner, General Counsel</div>
            </td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top;">&#160;</td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000;">/s/Alexander J. Denner</div>
            </td>
            <td style="width: 49.8%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: #000000;">Alexander J. Denner</div>
            </td>
            <td style="width: 49.8%; vertical-align: top;">&#160;</td>
          </tr>

      </table>
      <div><br>
      </div>
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                  <td style="width: 46.6%; vertical-align: top;">
                    <div style="font-size: 8pt;">CUSIP No. G01767105</div>
                  </td>
                  <td style="width: 53.4%; vertical-align: top;">
                    <div style="text-align: right; font-size: 8pt;">Page <font class="BRPFPageNumber">4</font> of 4 Pages</div>
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            <div style="text-align: center; font-size: 8pt;">SCHEDULE 13D</div>
          </div>
        </div>
      </div>
      <div>
        <div style="text-align: center; color: #000000; font-weight: bold;">INDEX TO EXHIBITS</div>
      </div>
      <div>
        <div><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001520262/000119312521142486/d171777d8k.htm">Exhibit 1</a> - Form 8-K of the Issuer filed with the U.S. Securities and Exchange Commission on April 30, 2021
          (incorporated by reference in this Schedule 13D)*</div>
        <div><font style="color: #000000;"> </font><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000089914021000485/s42631058b.htm">Exhibit 2</a> - Joint Filing Agreement of the Reporting Persons, dated as of May 10, 2021*</div>
        <div><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000089914022000583/s54639944b.htm">Exhibit 3</a> - Press Release, July 6, 2022*</div>
        <div><font style="color: #000000;"> </font><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123028238/ny20009418x2_ex4.htm">Exhibit 4</a> - Press Release, June 5, 2023*</div>
        <div><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123029264/ny20009418x6_ex5.htm">Exhibit 5</a> - Press Release, June 9, 2023*</div>
        <div><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123029760/ny20009418x8_ex6.htm">Exhibit 6</a> - Press Release, June 13, 2023*</div>
        <div><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1577524/000114036123030189/ny20009418x10_ex7.htm">Exhibit 7</a> - Press Release, June 15, 2023*</div>
        <div><br>
        </div>
        <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1577524/000114036123030633/brhc20054642_ex8.htm">Exhibit 8</a> - Press Release, June 20, 2023*</div>
        <div><br>
        </div>
        <div style="color: #000000;"><a href="brhc20054765_ex9.htm">Exhibit 9</a> - Press Release, June 22, 2023</div>
        <div><br>
        </div>
        <div style="color: #000000;">&#160;* Previously filed.</div>
      </div>
      <div><br>
      </div>
      <br>
    </div>
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<DOCUMENT>
<TYPE>EX-99.9
<SEQUENCE>2
<FILENAME>brhc20054765_ex9.htm
<DESCRIPTION>EXHIBIT 9
<TEXT>
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    <div>
      <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">EXHIBIT 9</div>
      <div>&#160;</div>
    </div>
    <div>
      <div style="text-align: center; font-weight: bold;"><a name="z_Hlk138237426"></a>INDEPENDENT PROXY ADVISORY FIRM ISS AGREES WITH SARISSA CAPITAL THAT SHAREHOLDERS&#8217; INTERESTS WOULD BE BEST SERVED WITH DIRECT SHAREHOLDER REPRESENTATION ON THE ALKERMES
        BOARD</div>
      <div><br>
      </div>
      <div style="text-align: center; font-style: italic;">Questions the integrity of Chairman and CEO Richard Pops and the accuracy of what management has communicated to the Alkermes Board</div>
      <div><br>
      </div>
      <div style="text-align: center; font-style: italic;">Concludes that Alkermes&#8217; leadership lacks either the ability or desire to manage its exorbitant spending</div>
      <div><br>
      </div>
      <div style="text-align: center; font-style: italic;">Determines that absent shareholder representation on the Board, Alkermes may &#8220;squander&#8221; the &#8220;windfall&#8221; from the recent Janssen decision</div>
      <div><br>
      </div>
      <div style="text-align: justify;">Greenwich, CT, June 22, 2023 &#8211; Sarissa Capital Management LP (&#8220;Sarissa&#8221;) today made the following additional statement regarding the recent report on Alkermes plc (NASDAQ: ALKS) issued by independent proxy advisory
        firm Institutional Shareholder Services Inc. (&#8220;ISS&#8221;):</div>
      <div><br>
      </div>
      <div style="text-align: justify;">We commenced this proxy contest on the basis that shareholder representation is essential for Alkermes to reach its true potential. The company has long suffered under the leadership of Chairman and CEO Richard Pops,
        and the Board has failed to hold him and other members of management accountable, to the significant detriment of the owners of the company&#8212;its shareholders. To the contrary, at the urging of Pops, the Board has allowed management to spend almost
        $10 million dollars of shareholder capital to keep the company&#8217;s largest active shareholder, who has a stellar track record and a position worth more than $450 million, out of the boardroom.</div>
      <div><br>
      </div>
      <div style="text-align: justify;">Shareholders should ask themselves a simple question &#8211; why would a purportedly well-functioning company undertake such actions? The answer is simple: the Board is dominated by a CEO with a tenure of 30 years who has
        a history of profligate spending, and the last thing that Pops (and his controlled Board) want is a real change agent that will provide the necessary oversight and accountability to run the company for the benefit of its true owners.</div>
      <div><br>
      </div>
      <div style="text-align: justify;">You don&#8217;t need to take our word for these conclusions. ISS has validated our position and concluded that Sarissa has &#8220;<font style="font-weight: bold; font-style: italic;">made a compelling case that this is the right
          moment for incremental change in the boardroom</font>.&#8221;</div>
      <div><br>
      </div>
      <div style="text-align: justify;">Among other concerns about Alkermes, ISS stated in its recent report that:</div>
      <div><br>
      </div>
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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>&#8220;[T]he persistently negative operating margins, <font style="font-weight: bold; font-style: italic;">even in the face of the company's commitment to profitability targets, is troubling</font>&#8221;;</div>
            </td>
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      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4d17c0e7aa894cbca98591ca6227f32d">

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            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>&#8220;[T]he implication of this trend [significant increases in SG&amp;A spend relative to sales] is that the <font style="font-weight: bold; font-style: italic;">company's leadership lacks either the ability or the desire to reduce spending
                  relative to revenue</font>&#8221;;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z84f0bd184d0a4d91a398f30d74d34f1a">

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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>&#8220;[T]he <font style="font-weight: bold; font-style: italic;">persistent negative return on investment at ALKS is unsustainable</font>. Whereas peers have demonstrated that positive ROIC is at least possible, ALKS shareholders have not
                experienced it in many years&#8221;;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zff9c78f1c20b41e9b16dcfd9a7c4bcdd">

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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>&#8220;<font style="font-weight: bold; font-style: italic;">The persistently low gross margin is the problem</font>, not the change in recent quarters. For reference, if ALKS had achieved gross margins in line with the peer median since the
                introduction of the [Value Enhancement Plan], <font style="font-weight: bold; font-style: italic;">it would have delivered approximately $370 million more gross profit between Q4 2020 and Q1 2023</font>&#8221;;</div>
            </td>
          </tr>

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            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div><font style="font-weight: bold; font-style: italic;">&#8220;[T]he board's ability to oversee management may be constrained by the combined long tenures of the Chairman/CEO [Richard Pops] (in CEO role since 1991) and [Nancy Wysenski] the lead
                  independent director (10-year board tenure)</font>. The&#8230;obstacles to direct interaction between Sarissa and independent directors <font style="font-weight: bold; font-style: italic;">raises questions about the accuracy of what was
                  communicated to the board and the dissident by management</font>&#8221;; and</div>
            </td>
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      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zeb94be486bd040a8aaee2c4118679bb5">

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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>&#8220;[T]he <font style="font-weight: bold; font-style: italic;">company's leadership has not demonstrated a commitment to lowering costs as a percent of revenues</font>, and there is risk that the spending windfall [from the Janssen
                settlement] <font style="font-weight: bold; font-style: italic;">will be squandered</font>&#8230;&#8221;</div>
            </td>
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      </table>
      <div><br>
      </div>
      <div style="text-align: justify;">ISS concluded its analysis by stating that:</div>
      <div><br>
      </div>
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            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>Sarissa Capital &#8220;<font style="font-weight: bold; font-style: italic;">has made a compelling case that the prolonged inability of the incumbent leadership of Alkermes to transition to profitability warrants change in the boardroom</font>&#8221;;


                and</div>
            </td>
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      </table>
      <div><br>
      </div>
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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>A Sarissa Capital &#8220;<font style="font-weight: bold; font-style: italic;">nominee is needed on the board to add urgency and pressure on management to change</font>&#8221;;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify;">Fellow Alkermes shareholders face an important decision at the upcoming annual shareholder meeting. Like ISS, we believe it is important to add direct shareholder representation to the Alkermes board. In our view,
        shareholder representation is critical to unlock the true potential of Alkermes and to provide the necessary oversight and accountability to prevent a reversion to the status quo of the last 30 years of underperformance under the leadership of
        Chairman and CEO Richard Pops. We hope that shareholders will focus on the substance of the case for change that we have clearly made, as reflected in the ISS report.</div>
      <div><br>
      </div>
      <div style="text-align: justify;">Your vote at Alkermes' Annual General Meeting of Shareholders on June 29, 2023 is very important.&#160; <font style="font-weight: bold;">We urge all shareholders to vote "<u>FOR</u>" the election of the Sarissa Nominees,
          &#8220;<u>AGAINST</u>&#8221; the compensation of the Company&#8217;s named executive officers, and "<u>FOR</u>" all other proposals in our proxy statement.</font></div>
      <div><br>
      </div>
      <div style="text-align: justify;">For additional information, please visit our website at upgradealkermes.com.</div>
      <div style="text-align: justify;">#UpgradeAlkermes</div>
      <div><br>
      </div>
      <div style="text-align: justify;">If you have any questions regarding your BLUE universal proxy card or need assistance in executing your proxy card, please contact:</div>
      <div><br>
      </div>
      <div style="font-weight: bold;">D.F.&#160; King &amp; Co., Inc.</div>
      <div>Shareholders call Toll-Free: (866) 207-3648</div>
      <div>All Others Call: (212) 493-6952</div>
      <div>Email: <u>ALKS@dfking.com</u></div>
      <div><br>
      </div>
      <div>You can vote in one of three easy ways: by internet at <u>www.cesvote.com</u>, by telephone at 1-888-693-8683 or by mail using the <font style="font-weight: bold;"><u>BLUE</u></font> universal proxy card and postage-paid envelope sent to you.</div>
      <div><br>
      </div>
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        <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-size: 8pt; color: #000000; font-weight: normal; font-style: normal;">- 2 - </font></div>
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      </div>
      <div>If you vote by internet or telephone, you will be required to provide the unique control number printed on your <font style="font-weight: bold;"><u>BLUE</u></font> universal proxy card.</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z608b5f34e0a746659f96acde4287fdee">

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            <td style="width: 72pt; vertical-align: top;">Contact:</td>
            <td style="width: auto; vertical-align: top;">
              <div>Dayna Packes</div>
              <div>
                <div>Sarissa Capital Management LP</div>
                <div><u>info@sarissacap.com</u></div>
              </div>
            </td>
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      </table>
      <br>
      <div style="font-weight: bold;">Additional Information</div>
      <div><br>
      </div>
      <div style="text-align: justify;">Sarissa Capital Management LP (&#8220;Sarissa Capital&#8221;), together with other participants, filed a definitive proxy statement and an accompanying BLUE universal proxy card with the SEC on June 2, 2023, in connection with
        the solicitation of shareholders of the Company for the 2023 annual general meeting of shareholders (the &#8220;Annual Meeting&#8221;).&#160; Shareholders are advised to read the definitive proxy statement and other documents related to the Annual Meeting as they
        contain important information.</div>
      <div><br>
      </div>
      <div style="text-align: justify;">The definitive proxy statement and other relevant documents are available at no charge on the SEC&#8217;s website at www.sec.gov.&#160; The definitive proxy statement and other relevant documents filed by Sarissa Capital are
        also available at no charge at www.upgradealkermes.com or by directing a request to Sarissa Capital&#8217;s proxy solicitor, D.F.&#160; King &amp; Co., Inc., 48 Wall Street, New York, New York 10005 (Shareholders can call toll-free: (866) 207-3648).</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div style="text-align: center;"><font class="BRPFPageNumber" style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;">- 3 - </font> </div>
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